Title:
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The genome-wide associated candidate gene ZNF804A and psychosis-proneness : evidence of sex-modulated association
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Author:
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De Castro-Catala, Marta; Mora-Solano, Aurea; Kwapil, Thomas; Cristóbal Narváez, Paula; Sheinbaum Frank, Tamara; Racioppi, Anna; Barrantes-Vidal, Neus; Rosa, Araceli
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Abstract:
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BACKGROUND: The Zinc finger protein 804A (ZNF804A) is a promising candidate gene for schizophrenia and the broader psychosis phenotype that emerged from genome-wide association studies. It is related to neurodevelopment and associated to severe symptoms of schizophrenia and alterations in brain structure, as well as positive schizotypal personality traits in non-clinical samples. Moreover, a female-specific association has been observed between ZNF804A and schizophrenia. AIM: The present study examined the association of two ZNF804A polymorphisms (rs1344706 and rs7597593) with the positive dimension of schizotypy and psychotic-like experiences in a sample of 808 non-clinical subjects. Additionally, we wanted to explore whether the sexual differences reported in schizophrenia are also present in psychosis-proneness. RESULTS: Our results showed an association between rs7597593 and both schizotypy and psychotic-like experiences. These associations were driven by females, such those carrying the C allele had higher scores in the positive dimension of both variables compared to TT allele homozygotes. CONCLUSION: The findings of the present study support the inclusion of ZNF804 variability in studies of the vulnerability for the development of psychopathology in non-clinical samples and consideration of sex as a moderator of this association |
Subject(s):
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-Adult -Female -Genetic predisposition to disease -Genome-wide association study -Humans -Kruppel-like transcription factors -Male -Polymorphism -Single nucleotide -Psychotic disorders -Schizophrenia -Sex factors |
Rights:
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open access
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Document type:
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Article |
Published by:
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Share:
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Uri:
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https://ddd.uab.cat/record/201194
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