dc.contributor.author |
Arrambide, Georgina |
dc.contributor.author |
Tintoré, Mar |
dc.contributor.author |
Auger, Cristina |
dc.contributor.author |
Río, Jordi |
dc.contributor.author |
Castilló, Joaquín |
dc.contributor.author |
Vidal-Jordana, Angela |
dc.contributor.author |
Galan, Ingrid |
dc.contributor.author |
Nos, Carlos |
dc.contributor.author |
Comabella, Manuel |
dc.contributor.author |
Mitjana, Raquel |
dc.contributor.author |
Mulero, P. |
dc.contributor.author |
de Barros, Andrea |
dc.contributor.author |
Rodríguez-Acevedo, Breogán |
dc.contributor.author |
Midaglia, Luciana |
dc.contributor.author |
Sastre-Garriga, Jaume |
dc.contributor.author |
Rovira, Alex |
dc.contributor.author |
Montalban, Xavier |
dc.date |
2017 |
dc.identifier |
https://ddd.uab.cat/record/186372 |
dc.identifier |
urn:10.1212/WNL.0000000000004715 |
dc.identifier |
urn:oai:ddd.uab.cat:186372 |
dc.identifier |
urn:pmid:29101276 |
dc.identifier |
urn:pmcid:PMC5719929 |
dc.identifier |
urn:pmc-uid:5719929 |
dc.identifier |
urn:articleid:1526632Xv89p2351 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/005d2e33-32de-4987-9675-9cfcc365e580 |
dc.identifier |
urn:scopus_id:85038238402 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:5719929 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Ministerio de Economía y Competitividad FIS/PI14-01439 |
dc.relation |
Ministerio de Economía y Competitividad FIS/CM10-00032 |
dc.relation |
Ministerio de Economía y Competitividad FIS/RD07-0060 |
dc.relation |
Ministerio de Economía y Competitividad FIS/RD12-0032 |
dc.relation |
Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-0793 |
dc.relation |
Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1082 |
dc.relation |
Neurology ; Vol. 89 (december 2017), p. 2351-2356 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
dc.rights |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.title |
Lesion topographies in multiple sclerosis diagnosis |
dc.type |
Article de revisió |
dc.type |
Article |
dc.description.abstract |
To assess the contributions of cortico-juxtacortical and corpus callosum lesions to multiple sclerosis diagnosis and to compare the value of ≥1 vs ≥3 periventricular lesions in clinically isolated syndromes (CIS). Step 1: We evaluated lesion topography classifications in 657 patients with CIS with stepwise Cox proportional hazards regression models considering second attack as the outcome. Step 2: We established 2 dissemination in space (DIS) versions according to the periventricular lesion cutoffs of ≥1 and ≥3 and assessed their performance at 10 years with second attack as the outcome, first individually and then combined with dissemination in time (DIT) in all cases (n = 326), by age, and by CIS topography. Step 1: The models (hazard ratios [95% confidence interval]) favored ≥1 over ≥3 periventricular lesions (2.5 [1.7-3.6]) and cortico-juxtacortical over juxtacortical lesions (1.4 [1.0-1.8]). Callosal lesions were not selected. Step 2: DIS specificity with ≥1 periventricular lesions was slightly lower than with ≥3 (59.1 vs 61.4) and the same after adding DIT (88.6). Regarding age, ≥3 periventricular lesions improved DIS specificity over ≥1 lesions in the 40-49 years of age bracket (66.7 vs 58.3). This difference disappeared when adding DIT (83.3). Optic neuritis had a similar pattern when evaluating CIS topographies. Our results comply with the Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) consensus recommendation of combining cortical and juxtacortical lesions into a single term when possible. Concerning periventricular lesions, maintaining the current ≥1 cutoff in the McDonald criteria does not compromise specificity in typical CIS cases, but attention should be paid to older patients or optic neuritis cases. |