dc.contributor.author |
Vallecillo Sánchez, Gabriel |
dc.contributor.author |
Mojal, Sergio |
dc.contributor.author |
Torrens, Marta |
dc.contributor.author |
Muga, Roberto |
dc.date |
2014 |
dc.identifier |
https://ddd.uab.cat/record/185268 |
dc.identifier |
urn:10.1093/ofid/ofu010 |
dc.identifier |
urn:oai:ddd.uab.cat:185268 |
dc.identifier |
urn:pmid:25734084 |
dc.identifier |
urn:pmcid:PMC4324207 |
dc.identifier |
urn:pmc-uid:4324207 |
dc.identifier |
urn:scopus_id:84978328057 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/809e836f-daef-4478-95ad-adf48d301696 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:4324207 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Open Forum Infectious Diseases ; Vol. 1 (june 2014) |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
dc.rights |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.subject |
Antiretroviral therapy |
dc.subject |
HIV-infected drug users |
dc.subject |
Hospitalization |
dc.title |
Antiretroviral Therapy (ART) Use, Human Immunodeficiency Virus (HIV)-1 RNA Suppression, and Medical Causes of Hospitalization Among HIV-Infected Intravenous Drug Users in the Late ART Era |
dc.type |
Article |
dc.description.abstract |
Background: Antiretroviral therapy (ART) has reduced the rates and changed the causes of hospital admission. However, human immunodeficiency virus-positive intravenous drug users (HIV-IDU) continue to have increased hospitalizations and discharge diagnosis are less defined in the late ART era. Our aim was to examine ART use, HIV-1 RNA suppression, and hospital discharge diagnoses among HIV-IDU admitted to an urban hospital.Methods: A retrospective analysis was made of HIV-IDU admitted for medical causes for the first time (2006-2010). Surgical, obstetric, or mental (except HIV-associated neurocognitive disorder) diagnoses were excluded. Clinical characteristics, number of admissions, and primary discharge diagnoses were determined for each patient.Results: Three hundred and seventy-five admissions were recorded among 197 hospitalized HIV-IDU. Lifetime prevalence of ART use was 83.2% (164 of 197) and the rate of HIV-1 RNA <50 copies/mL was 38.1% (75 of 197). Primary discharge diagnosis groups were as follows:acterial infections (59.2%), chronic end-organ damage (16.8%), complications derived from injected drug use (16.8%), malignancies (9.1%), and opportunistic infections (6.6%). Chronic end-organ damage was diagnosed more frequently in patients with HIV-1 RNA <50 copies/mL (36% vs 4.9%; P < .000), and complications derived from injected drug use (23.8% vs 5.3%; P < .0008) and acquired immune deficiency syndrome (AIDS) opportunistic infections (19.8% vs 1.3% P < .019) were usually diagnosed in patients with HIV-1 RNA detectable viral load. Conclusions: Human immunodeficiency virus-positive intravenous drug users are admitted to hospitals mainly for non-AIDS-related illnesses; however, sustained HIV-1 RNA viral load suppression is poor and determines hospital discharge diagnoses. Providers need to be aware of the management of HIV-related comorbidities and reinforce strategies to improve ART retention in this population. |