dc.contributor.author |
Gimenez-Llort, Lydia |
dc.contributor.author |
García, Yoelvis |
dc.contributor.author |
Buccieri, Karla |
dc.contributor.author |
Revilla, Susana |
dc.contributor.author |
Suñol, Cristina |
dc.contributor.author |
Cristofol, Rosa |
dc.contributor.author |
Sanfeliu i Pujol, Coral |
dc.contributor.author |
Universitat Autònoma de Barcelona |
dc.date |
2010 |
dc.identifier |
https://ddd.uab.cat/record/183241 |
dc.identifier |
urn:10.4061/2010/128354 |
dc.identifier |
urn:oai:ddd.uab.cat:183241 |
dc.identifier |
urn:pmid:20981262 |
dc.identifier |
urn:pmcid:PMC2964036 |
dc.identifier |
urn:pmc-uid:2964036 |
dc.identifier |
urn:wos_id:000208765500025 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/2e455d62-9b9f-4937-91e8-7d8ccb6365f8 |
dc.identifier |
urn:altmetric_id:56516731 |
dc.identifier |
urn:scopus_id:78349250222 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:2964036 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Instituto de Salud Carlos III RD06/0013-0003 |
dc.relation |
Instituto de Salud Carlos III RD06-0013-1004 |
dc.relation |
Ministerio de Ciencia e Innovación SAF2006-13642 |
dc.relation |
Ministerio de Ciencia e Innovación SAF2009-13093-C02-02 |
dc.relation |
International Journal of Alzheimer's Disease ; Vol. 2010 (10 2010) |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.title |
Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice |
dc.type |
Article |
dc.description.abstract |
The 3xTg-AD mouse develops a progressive Alzheimer's disease- (AD-) like brain pathology that causes cognitive- and neuropsychiatric-like symptoms of dementia. Since its neuroimmunoendocrine axis is likewise impaired, this mouse is also useful for modelling complex age-related neurodegeneration. This study analyzed behavioral, physiological, neurochemical, pathological and immunoendocrine alterations in male and female 3xTg-AD mice and assayed the effects of a short therapy of forced physical exercise at the moderate pathology stage of 6 months of age. Gender effects were observed in most AD-related pathology and dysfunctions. Five weeks of treadmill training produced beneficial effects, such as the reduction of brain oxidative stress and GABA-A receptor dysfunction in males and improvement of sensorimotor function in females. In both sexes, exercise decreased the brain amyloid β 42/40 ratio levels. The results highlight the importance of analyzing experimental therapies in both mouse model genders in order to improve our understanding of the disease and develop more appropriate therapies. |