dc.contributor.author
Li, Bowen
dc.contributor.author
Alfonso, Valero G.
dc.contributor.author
Puggioli, Alessio
dc.contributor.author
Solé-Daura, Albert
dc.contributor.author
Maseras, Feliu
dc.contributor.author
Suero, Marcos G.
dc.date.accessioned
2025-07-09T12:52:00Z
dc.date.available
2025-07-09T12:52:00Z
dc.date.issued
2025-07-07
dc.identifier.uri
http://hdl.handle.net/2072/484508
dc.description.abstract
Single-carbon insertion processes have gained considerable momentum over the past few years. Although innovative methods have emerged for converting indole or indene into quinoline or naphthalene cores, the enantioselective version of such ring-expansions to create (hetero)biaryl atropisomers has not been developed. Herein, we report the first enantioselective single-carbon insertion that converts 3-aryl indoles to atropochiral quinolines. Key in the process was the generation of a chiral Rh-carbynoid that mediated in the creation of the stereogenic C(sp2)–C(sp2) axis.
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dc.publisher
ACS Publications
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dc.rights
Attribution 4.0 International
*
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
*
dc.source
RECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.other
Química
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dc.title
Rh-Catalyzed Atroposelective Single-Carbon Insertion
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dc.type
info:eu-repo/semantics/article
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dc.description.version
info:eu-repo/semantics/publishedVersion
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dc.relation.projectID
European Research Council (ERC-CoG 2019, 865554)
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dc.relation.projectID
Agencia Estatal de Investigación of the Ministerio de Ciencia, Innovación y Universidades (MICIU/AEI/10.13039/501100011033) and FEDER (PID2022-140286NB-I00, PID2023-149479NB-I00, Severo Ochoa Excellence Accreditation CEX2024-001469-S)
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dc.relation.projectID
ICIQ Foundation
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dc.relation.projectID
ICREA Foundation
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dc.relation.projectID
CERCA Program/Generalitat de Catalunya
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dc.relation.projectID
European Union for a Marie Skłodowska-Curie Individual Fellowship (101110735 to B.L.)
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dc.relation.projectID
AGAUR for a FI predoctoral fellowship (2022 FI_B 00540 to V.G.A.)
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dc.relation.projectID
AEI (and FSE+) for a predoctoral fellowship (PRE2021-097799 to A.P.)
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dc.relation.projectID
AEI (and FSE+) for a Juan de la Cierva fellowship (JDC2022-048825-I to B.L.).
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dc.relation.projectID
A.S.-D. acknowledges financial support from the “la Caixa” Foundation (ID 100010434) under the fellowship code LCF/BQ/PI24/12040012.
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dc.identifier.doi
https://doi.org/10.1021/jacs.5c06139
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dc.rights.accessLevel
info:eu-repo/semantics/openAccess
