A unique Helicobacter pylori strain to study gastric cancer development

Altres ajuts: National Institutes of Health (NIH), R21AI140038, AI118932, AI039657, CA11608722 ; U.S. Department of Veterans Affairs (VA), 2 I01 BX004447

Gastric cancer is the fifth leading cause of cancer-related death globally; the majority of gastric cancers are associated with Helicobacter pylori infection. Infection of Mongolian gerbils with H. pylor i has been shown to result in induction of gastric cancer, but few H. pylori strains have been studied in this model; this limits our ability to fully understand gastric cancer pathogenesis in humans because H. pylori strains are notoriously heterogenous. Our studies reveal that USU101 represents a unique H. pylori strain that can be added to our repertoire of strains to study gastric cancer development in the Mongolian gerbil model.

Document Type

Article

Language

English

Subjects and keywords

H. pylori; Mongolian gerbils; Gastric adenocarcinoma; CagA; VacA

Publisher

Related items

Microbiology Spectrum ; Vol. 13 (december 2024)

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open access

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Articles escrits per personal UAB o publicats per la universitat [88076]