IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer: Recent submissions
Now showing items 1-20 of 3164
Rituximab is a safe and effective alternative treatment for patients with autoimmune hepatitis: Results from the ColHai registry
Background and Aims: Small series suggest that rituximab could be effective as treatment for autoimmune hepatitis (AIH), although data are scarce. We aimed to evaluate the efficacy and safety of rituximab in different ...
Metabolic Singularities in Microsatellite-Stable Colorectal Cancer: Identifying Key Players in Immunosuppression to Improve the Immunotherapy Response.
Although immune checkpoint inhibitor (ICI) therapy is currently the standard of care in microsatellite-unstable (MSI) metastatic colorectal cancer (CRC), ICI therapy, alone or in combination with other therapies, is not a ...
Lesions mimicking colonic polyposis
[No abstract available]
Fatal Langerhans Cell Histiocytosis in an 84-Year-Old Man: A Case Report
[No abstract available]
Long-term outcome and risk stratification in compensated advanced chronic liver disease after HCV-cure
Background & Rationale: Around 750.000 patients/year will be cured from hepatitis C-virus (HCV)-infection until 2030. Those with compensated advanced chronic liver disease (cACLD) remain at risk for hepatic decompensation ...
Obesity Is Increasing in Liver Transplant Recipients and Exacerbates Cardiovascular Risk: A Single-Centre European Study
Purpose Recent changes in the profile of liver transplant (LT) recipients include an increasing number of patients with metabolic-associated steatotic liver disease (MASLD), which is associated with obesity and cardiovascular ...
Perivascular and parenchymal brain fluid diffusivity in patients with a recent small subcortical infarct
Purpose Fluid exchanges between perivascular spaces (PVS) and interstitium may contribute to the pathophysiology of small vessel disease (SVD). We aimed to analyze water diffusivity measures and their relationship with PVS ...
Basal Serum Tryptase Outperforms Hereditary Alpha Tryptasemia as a Biomarker of Food Allergy Severity
[No abstract available]
A Worrisome Liver Doppelgänger
[No abstract available]
Polygenic risk scores mediating functioning outcomes through cognitive and clinical features in youth at family risk and controls
Schizophrenia and bipolar disorder exhibit substantial clinical overlap, particularly in individuals at familial high risk, who frequently present sub-threshold symptoms before the onset of illness. Severe mental disorders ...
One-quarter of chronic hepatitis D patients reach HDV-RNA decline or undetectability during the natural course of the disease
Spontaneous HDV-RNA fluctuations, assessed by nonstandardised in-house assays, have been reported during the course of chronic hepatitis delta (CHD).To evaluate changes in serum HDV-RNA concentrations in untreated CHD ...
Incidence and Clinical Significance of Recompensation After HCV Cure
BACKGROUND & AIMS: Baveno VII has proposed criteria for cirrhosis recompensation, but their prognostic significance in decompensated patients cured of hepatitis C virus (HCV) deserves further investigation. Thus, we ...
Tracking B cell immunity during perturbation of hepatitis B infection induced by treatment withdrawal
Background Withdrawal of prolonged nucleos(t)ide analogue (NA) treatment results in hepatitis B surface antigen (HBsAg) loss in some subjects with chronic hepatitis B (CHB), potentially revealing immune correlates of ...
HBcrAg and cirB-RNA Do Not Predict Clinical and Virological Outcomes in Patients With HBeAg-Negative Chronic Infection
Background & Aims: Predicting clinical and virological outcomes in HBeAg-negative (HBeAg-neg) chronic infection often requires long-term monitoring. Our study explored whether a single measurement of quantitative HBsAg ...
Hepatic encephalopathy and MELD-Na predict treatment benefit in autoimmune hepatitis-related decompensated cirrhosis.
Management of patients with autoimmune hepatitis (AIH)-related decompensated cirrhosis is challenging because of the risk of treatment-related complications and lack of clinical recommendations. We investigated the predictive ...
HBV Suppression by Nucleos(t)ide Analogues Reduces PD-1 Expression on Liver-Resident T Cells
Background and Aim: PD-1-expressing T cells within the HBV-infected liver constitute a target of novel immunotherapeutics. Our aim was to investigate the impact of viral suppression on PD-1 expression on intrahepatic versus ...
Post-treatment LSM rather than change during treatment predicts decompensation in patients with cACLD after HCV cure
Background & Aims: Baveno VII has defined a clinically significant ( i.e. , prognostically meaningful) decrease in liver stiffness measurement (LSM) in cACLD as a decrease of >-20% associated with a final LSM -20 ...
Assessment of childhood maltreatment in pharmacotherapy trials for schizophrenia.
Schizophrenia spectrum disorders (SSD) are among the leading global causes of disability, owing to chronic trajectories and high rates of treatment resistance. Antipsychotic medications are generally effective, but in up ...
Comparison of inferior vena cava filter use and outcomes between cancer and non-cancer patients in a tertiary hospital
Background: While accepted indications for the use of inferior vena cava filter (IVCF) in patients with a venous thromboembolism (VTE) have remained stable, their use continues to be frequent. Retrieval rates are still ...
The Role of Audiometry prior to High-Dose Cisplatin in Patients with Head and Neck Cancer.
To analyze the role of audiometry in considering change to a less ototoxic treatment in head and neck cancer (HNC) patients.Consecutive patients prescribed high-dose cisplatin (100 mg/m2) between January 2013 and February ...
