dc.contributor.author |
Harrison, Ben J. |
dc.contributor.author |
Pujol Nuez, Jesús |
dc.contributor.author |
Contreras Rodríguez, Oren |
dc.contributor.author |
Soriano-Mas, Carles |
dc.contributor.author |
López Solà, Marina |
dc.contributor.author |
Deus Yela, Juan |
dc.contributor.author |
Ortiz Valencia, Héctor |
dc.contributor.author |
Blanco Hinojo, Laura |
dc.contributor.author |
Alonso, Pino |
dc.contributor.author |
Hernández Ribas, Rosa |
dc.contributor.author |
Cardoner, N. (Narcís) |
dc.contributor.author |
Menchón Magriñá, José Manuel |
dc.date |
2011 |
dc.identifier |
https://ddd.uab.cat/record/109303 |
dc.identifier |
urn:10.1371/journal.pone.0022964 |
dc.identifier |
urn:oai:ddd.uab.cat:109303 |
dc.identifier |
urn:pmid:21829564 |
dc.identifier |
urn:recercauab:ARE-65566 |
dc.identifier |
urn:articleid:19326203v6n7e22964 |
dc.identifier |
urn:scopus_id:79960905876 |
dc.identifier |
urn:wos_id:000293286500057 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/cce88903-8cf7-43de-8b8d-df8e1659c56b |
dc.identifier |
urn:pmc-uid:3146521 |
dc.identifier |
urn:pmcid:PMC3146521 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:3146521 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
PloS one ; Vol. 6, Issue 7 (July 2011), p. e22964 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/2.0/ |
dc.subject |
Neurologia |
dc.subject |
Cervell |
dc.subject |
Regiones cerebrales |
dc.subject |
Brain regions |
dc.title |
Task-induced deactivation from rest extends beyond the default mode brain network |
dc.type |
Article |
dc.description.abstract |
Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized 'default-mode network' (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes. |