Recent submissions

SEOM-GEMCAD-TTD Clinical Guideline for the diagnosis and treatment of esophageal cancer (2021)

Fernández Montes, Ana; Alcaide, Julia; Alsina Maqueda, Maria; Custodio, Ana; Fernández Franco, Lourdes; Gallego Plazas, Javier (Publication date: 2022-08-12)

Diagnosis; Esophageal cancer; Treatment

Tepotinib Efficacy and Safety in Patients with MET Exon 14 Skipping NSCLC: Outcomes in Patient Subgroups from the VISION Study with Relevance for Clinical Practice

Sakai, Hiroshi; Veillon, Remi; Garassino, Marina Chiara; Raskin, Jo; Le, Xiuning; Felip Font, Enriqueta (Publication date: 2023-04-18)

Efficacy; Lung cancer

Targeting HER2-AXL heterodimerization to overcome resistance to HER2 blockade in breast cancer

ADAM-ARTIGUES, ANNA; Brasó-Maristany, Fara; Cervera Vidal, Raimundo; Tormo, Eduardo; Arribas López, Joaquin Vicente; Arenas Lahuerta, Enrique Javier; Martínez-Sabadell, Alex (Publication date: 2022-09-09)

Breast cancer; Heterodimerization

Protocol to generate a patient derived xenograft model of acquired resistance to immunotherapy in humanized mice

Ovejero Romero, Pablo; Arribas López, Joaquin Vicente; Arenas Lahuerta, Enrique Javier; Martínez-Sabadell, Alex (Publication date: 2022-11-28)

Cancer; Cell isolation; Stem cells

Prognostic value of HER2DX in early-stage HER2-positive breast cancer: a comprehensive analysis of 757 patients in the Sweden Cancerome Analysis Network—Breast dataset (SCAN-B)

Villacampa Javierre, Guillermo; Pascual, Tomás; Brasó Maristany, Fara; Paré, Laia; Martínez-Sáez, Olga; Cortes, Javier (Publication date: 2024-03-11)

Breast cancer; Chemotherapy; Trastuzumab

The role of eosinophil morphology in distinguishing between reactive eosinophilia and eosinophilia as a feature of a myeloid neoplasm

Goasguen, Jean E.; Bennett, John M.; Bain, Barbara J.; Brunning, Richard; Zini, Gina; Vallespi Sole, Maria Teresa (Publication date: 2021-11-05)

Eosinófilos; Morfología; Neoplasia mieloide

The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance

Lawson, Mandy; Cureton, Natalie; Ros, Susana; Cheraghchi-Bashi, Azadeh; Urosevic, Jelena; D'Arcy, Sophie; Serra, Violeta (Publication date: 2023-12-20)

Estrogen receptor; Breast cancer; Endocrine inhibitor

LIX1 Controls MAPK Signaling Reactivation and Contributes to GIST-T1 Cell Resistance to Imatinib

Ruiz Demoulin, Salomé; Trenquier, Eva; Dekkar, Sanaa; Deshayes, Sebastien; Boisguerin, Prisca; Serrano, Cesar (Publication date: 2023-05-08)

Gastrointestinal tumors; Tyrosine kinase inhibitors

Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis

A Salahudeen, Ameen; Yuki, Kanako; Mah, Amanda T.; Smith, Amber R.; Kolahi, Kevin; Seoane, Joan (Publication date: 2023-11-17)

Genomics; Organoid; Squamous cancer

The effect of age on efficacy, safety and patient-centered outcomes with rucaparib: A post hoc exploratory analysis of ARIEL3, a phase 3, randomized, maintenance study in patients with recurrent ovarian carcinoma

Oza, Amit M.; Lorusso, Domenica; Oaknin Benzaquen, Ana Mazaltob; Dean, Andrew; Colombo, Nicoletta; Aghajanian, Carol (Publication date: 2021-09-23)

Pacients d'edat avançada; Càncer d'ovaris; Inhibidor de la PARP

Impact of Primary Breast Surgery on Overall Survival of Patients With De Novo Metastatic Breast Cancer: A Systematic Review and Meta-Analysis

Fredriksson, Irma; Matikas, Alexios; Villacampa Javierre, Guillermo; Papakonstantinou, Andri (Publication date: 2024-01-29)

Breast surgery; Metastatic; Overall survival

Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors

Lahiguera, Álvaro; Hyroššová, Petra; Figueras, Agnès; Garzón, Diana; Moreno, Roger; Soto-Cerrato, Vanessa; Serra Elizalde, Violeta (Publication date: 2021-09-09)

Inhibidors de la PARP; Metabolisme del càncer; Metformina

Adjuvant Trastuzumab Emtansine Versus Paclitaxel Plus Trastuzumab for Stage I Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: 5-Year Results and Correlative Analyses From ATEMPT

Tarantino, Paolo; Tayob, Nabihah; DANG, CHAU; Yardley, Denise A.; Villacampa Javierre, Guillermo; Isakoff, Steven (Publication date: 2024-11-19)

Paclitaxel; Cáncer de mama; Factor de crecimiento epidérmico

Metformin induces a fasting- and antifolate-mimicking modification of systemic host metabolism in breast cancer patients

Cuyàs, Elisabet; Fernández-Arroyo, Salvador; Buxó, Maria; Pernas, Sonia; Dorca, Joan; Álvarez, Isabel; Cortés Castan, Javier (Publication date: 2021-03-23)

Homocisteïna; Càncer de mama; Dieta cetogènica

Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness

Levy, Pierre; Alflen, Astrid; Apriamashvili, Georgi; ligtenberg, maarten; Vredevoogd, David; Lin, Chun-Pu (Publication date: 2024-04-16)

Cèl·lules T; Mort cel·lular induïda per l'activació; Immunoteràpia contra el càncer

Prognostic Models From Transcriptomic Signatures of the Tumor Microenvironment and Cell Cycle in Stage III Colon Cancer From PETACC-8 and IDEA-France Trials

SROUSSI, Marine; MOUILLET-RICHARD, Sophie; Agueeff, Natacha; Mulot, Claire; Gallois, Claire; André, Thierry; Tabernero, Josep (Publication date: 2025-07-04)

Prognostic models; Tumor microenvironment; Colon cancer

Clinical Behavior of Breast Cancer in Young BRCA Carriers and Prediagnostic Awareness of Germline BRCA Status

Tomasello, Loredana Maria Tomasello; kim , hee jeong; Lambertini, Matteo; Blondeaux, Eva; Agostinetto, Elisa; HAMY, Anne-Sophie; Balmaña, Judith (Publication date: 2025-07-04)

Càncer de mama; Línia germinal BRCA

AML typical mutations (CEBPA, FLT3, NPM1) identify a high-risk chronic myelomonocytic leukemia independent of CPSS molecular

Castaño-Díez, Sandra; Zugasti, Ines; Calvo, Xavier; Schulz, Felicitas; Avendaño, Alejandro; Palomo Sanchis, Laura; POMARES, HELENA; Vila Bou, Jordi; Lopez-Guerra, Monica (Publication date: 2025-05-28)

Leucèmia mielomonocítica crònica; Leucèmia mieloide aguda; Mutació

Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes

Celada, Lucía; RUIZ-CANTADOR, JOSE; da Silva Alves Pereira, Bianca Gabriela; Iglesias Felip, Carmela; Casteràs, Anna; Arenillas, Carlota; Calsina, Bruna; Datta, Debayan; García-Galea, Eduardo; fasani, roberta; Moreno-Cárdenas, Ana Belén; Miranda, Berta; Dienstmann, Rodrigo; Villanueva Cardús, Josep; Capdevila Castillon, Jaume; Nuciforo, Paolo; DOS SUBIRA, LAURA; Toledo, Rodrigo (Publication date: 2025-05-20)

Genetic; Human tumors; Systemic hypoxia

A phase Ia study of the MEK1/2 inhibitor PD-0325901 with the c-MET inhibitor crizotinib in patients with advanced solid cancers

Gallagher, Peter; Rolfo, Christian; Elez, Elena; Houlden, Jennifer; Collins, Linda; taieb, julien; Tabernero, Josep (Publication date: 2025-05-12)

MEK1/2 inhibitor; C-MET inhibitor crizotinib; Advanced solid cancers

Articles científics - VHIO: Recent submissions

SEOM-GEMCAD-TTD Clinical Guideline for the diagnosis and treatment of esophageal cancer (2021) ﻿

Tepotinib Efficacy and Safety in Patients with MET Exon 14 Skipping NSCLC: Outcomes in Patient Subgroups from the VISION Study with Relevance for Clinical Practice ﻿

Targeting HER2-AXL heterodimerization to overcome resistance to HER2 blockade in breast cancer ﻿

Protocol to generate a patient derived xenograft model of acquired resistance to immunotherapy in humanized mice ﻿

Prognostic value of HER2DX in early-stage HER2-positive breast cancer: a comprehensive analysis of 757 patients in the Sweden Cancerome Analysis Network—Breast dataset (SCAN-B) ﻿

The role of eosinophil morphology in distinguishing between reactive eosinophilia and eosinophilia as a feature of a myeloid neoplasm ﻿

The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance ﻿

LIX1 Controls MAPK Signaling Reactivation and Contributes to GIST-T1 Cell Resistance to Imatinib ﻿

Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis ﻿

The effect of age on efficacy, safety and patient-centered outcomes with rucaparib: A post hoc exploratory analysis of ARIEL3, a phase 3, randomized, maintenance study in patients with recurrent ovarian carcinoma ﻿

Impact of Primary Breast Surgery on Overall Survival of Patients With De Novo Metastatic Breast Cancer: A Systematic Review and Meta-Analysis ﻿

Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors ﻿

Adjuvant Trastuzumab Emtansine Versus Paclitaxel Plus Trastuzumab for Stage I Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: 5-Year Results and Correlative Analyses From ATEMPT ﻿

Metformin induces a fasting- and antifolate-mimicking modification of systemic host metabolism in breast cancer patients ﻿

Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness ﻿

Prognostic Models From Transcriptomic Signatures of the Tumor Microenvironment and Cell Cycle in Stage III Colon Cancer From PETACC-8 and IDEA-France Trials ﻿

Clinical Behavior of Breast Cancer in Young BRCA Carriers and Prediagnostic Awareness of Germline BRCA Status ﻿

AML typical mutations (CEBPA, FLT3, NPM1) identify a high-risk chronic myelomonocytic leukemia independent of CPSS molecular ﻿

Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes ﻿

A phase Ia study of the MEK1/2 inhibitor PD-0325901 with the c-MET inhibitor crizotinib in patients with advanced solid cancers ﻿