Título:
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Diastereodivergent Enantioselective [8+2] Annulation of Tro- pones and Enals Catalyzed by N-Heterocyclic Carbenes
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Autor/a:
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Wang, Shoulei; Rodríguez-Escrich, Carles; Fianchini, Mauro; Maseras, Feliu; Pericàs, Miquel A.
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Abstract:
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N-Heterocyclic carbene (NHC) catalysts are used for the first time to mediate asymmetric [8+2] cycloadditions of enals with tropones. The kinetic [8+2] cis-cycloadducts can be epimerized to their trans analogues by simply using increased amounts of base and longer reaction times. Substituted tropones are also tolerated, and the cycloaddition products can be derivatized by hydrogenation or methanolysis. The main stereochemical features on the results of DFT calculations. |
Fecha de creación:
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23-04-2019 |
Materia(s):
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54 |
Derechos:
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L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Páginas:
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3187 p. |
Tipo de documento:
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Artículo Artículo - Versión aceptada |
DOI:
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10.1021/acs.orglett.9b00906
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