dc.contributor.author |
Vázquez-Oliver, Anna |
dc.contributor.author |
Brambilla Pisoni, Cecilia |
dc.contributor.author |
Domingo-Gainza, Mikel |
dc.contributor.author |
Maldonado, Rafael, 1961- |
dc.contributor.author |
Ivorra Cano, Antoni, 1974- |
dc.contributor.author |
Ozaita Mintegui, Andrés, 1969- |
dc.date |
2019 |
dc.identifier.citation |
Vázquez-Oliver A, Brambilla-Pisone C, Domingo-Gainza, M, Maldonado R, Ivorra A, Ozaita A. Auricular transcutaneous vagus nerve stimulation improves memory
persistence in naïve mice and in an intellectual disability mouse model. Brain estimulation. 2019 [Epub ahead of print].
DOI: 10.1016/j.brs.2019.12.024 |
dc.identifier.citation |
1935-861X |
dc.identifier.citation |
http://dx.doi.org/10.1016/j.brs.2019.12.024 |
dc.identifier.uri |
http://hdl.handle.net/10230/43233 |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Elsevier |
dc.relation |
info:eu-repo/grantAgreement/EC/H2020/713673 |
dc.relation |
info:eu-repo/grantAgreement/ES/2PE/SAF2017-84060-R |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
© 2019 Anna Vázquez-Oliver et al. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
dc.rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.subject |
Sistema nerviós |
dc.subject |
Memòria |
dc.title |
Auricular transcutaneous vagus nerve stimulation improves memory
persistence in naïve mice and in an intellectual disability mouse model |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
Data de publicació electrònica: 31-12-2019 |
dc.description.abstract |
Background: Vagus nerve stimulation (VNS) using non-invasive approaches have attracted great attention due to their anti-epileptic, anti-depressive and pro-cognitive effects. It has been proposed that auricular transcutaneous VNS (atVNS) could benefit intellectual disability disorders, but preclinical data supporting this idea is limited. Objective: To develop an atVNS device for mice and to test its efficacy on memory performance in naïve mice and in a mouse model for intellectual disability. Methods: Naïve outbreed CD-1 mice and a model for fragile X syndrome, the Fmr1 knockout (Fmr1KO), were used to assess the effect of atVNS in the novel object-recognition memory performance. Results: We found that atVNS significantly improves memory persistence in naïve mice. Notably, atVNS was efficacious in normalizing the object-recognition memory deficit in the Fmr1KO model. Conclusion: Our data show that atVNS improves memory persistence in naïve mice and in a model of intellectual disability and support further studies taking advantage of preclinical mouse models of cognitive disorders. |
dc.description.abstract |
This work was supported by a Predoctoral fellowship from Jerome Lejeune Foundation (Spanish division) (A.V.-O.) and from “la Caixa” Foundation (ID 100010434), LCF/BQ/IN18/11660012 and European Union’s Horizon 2020 research and innovation programme under the Marie Slodowska-Curie grant agreement No. 713673 (C.B.-P.). Ministerio de Economía, Innovación y Competitividad (MINECO) [#RTI2018-099282-B-I00 to A.O., #SAF2017-84060-R to R.M.]; the Instituto de Salud Carlos III [#RD16/0017/0020 to R.M.]; the Generalitat de Catalunya [2017SGR-669 to R.M.]; the ICREA (Institució Catalana de Recerca i Estudis Avançats) Acadèmia to A.O., A.I. and R.M.; Grant “Unidad de Excelencia María de Maeztu”, funded by the MINECO [#MDM-2014-0370]; PLAN E (Plan Español para el Estímulo de la Economía y el Empleo). FEDER (Fondo Europeo de Desarrollo Regional) funding is also acknowledged |