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Title:	Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder
Author:	Demirtaş, Murat; Tornador Antolin, Cristian, 1979-; Falcón, Carles; López-Solà, Marina; Hernández-Ribas, Rosa; Pujol, Jesús; Menchón, José M.; Ritter, Petra; Cardoner, Narcís; Deco, Gustavo
Abstract:	Resting-state fMRI (RS-fMRI) has become a useful tool to investigate the connectivity structure of mental health disorders. In the case of major depressive disorder (MDD), recent studies regarding the RS-fMRI have found abnormal connectivity in several regions of the brain, particularly in the default mode network (DMN). Thus, the relevance of the DMN to self-referential thoughts and ruminations has made the use of the resting-state approach particularly important for MDD. The majority of such research has relied on the grand averaged functional connectivity measures based on the temporal correlations between the BOLD time series of various brain regions. We, in our study, investigated the variations in the functional connectivity over time at global and local level using RS-fMRI BOLD time series of 27 MDD patients and 27 healthy control subjects. We found that global synchronization and temporal stability were significantly increased in the MDD patients. Furthermore, the participants with MDD showed significantly increased overall average (static) functional connectivity (sFC) but decreased variability of functional connectivity (vFC) within specific networks. Static FC increased to predominance among the regions pertaining to the default mode network (DMN), while the decreased variability of FC was observed in the connections between the DMN and the frontoparietal network.
Abstract:	ERC Advanced Grant: DYSTRUCTURE (to G.D.); Contract grant number: 295129; Contract grant sponsor:/nSpanish Research Project; Contract grant number: PSI2013-42091- P; Contract grant sponsor: European Union Seventh Framework Programme (FP7-ICT Human Brain Project; Contract grant number: 604102; Contract grant sponsor: del Carlos III Health Institute (to C.S.M.); Contract grant number: CP10/00604
Subject(s):	-Mood disorders -Major depressive disorder -Dynamic functional connectivity -Resting state -fMRI
Rights:	© 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc./nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. http://creativecommons.org/licenses/by-nc-nd/4.0/
Document type:	Article Article - Published version
Published by:	Wiley
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