Título:
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A novel statistical analysis and interpretation of flow cytometry data
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Autor/a:
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Banks, H.T.; Kapraun, Dustin F.; Thompson, W. Clayton; Peligero Cruz, Cristina, 1986-; Argilaguet, Jordi; Meyerhans, Andreas
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Abstract:
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A recently developed class of models incorporating the cyton model of population generation structure into a conservation-based model of intracellular label dynamics is reviewed. Statistical aspects of the data collection process are quantified and incorporated into a parameter estimation scheme. This scheme is then applied to experimental data for PHA-stimulated CD4+T and CD8+T cells collected from two healthy donors. This novel mathematical and statistical framework is shown to form the basis for accurate, meaningful analysis of cellular behaviour for a population of cells labelled with the dye carboxyfluorescein succinimidyl ester and stimulated to divide. |
Materia(s):
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-Cèl·lules T -Estadística matemàtica |
Derechos:
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© 2013 Taylor & Francis. This is an electronic version of an article published in Journal of biological dynamics. 2013. 7: 96-132. Journal of biological dynamics is available online at: www.tandfonline.com/doi/pdf/10.1080/17513758.2013.812753
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Tipo de documento:
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Artículo Artículo - Versión publicada |
Editor:
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Taylor & Francis (Routledge)
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