An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis

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dc.contributor.author	Meunier, Sylvain
dc.contributor.author	Shvedunova, Maria
dc.contributor.author	Van Nguyen, Nhuong
dc.contributor.author	Ávila, Leonor
dc.contributor.author	Vernos, Isabelle, 1959-
dc.contributor.author	Akhtar, Asifa
dc.date	2015
dc.identifier.citation	Meunier S, Shvedunova M, Van Nguyen N, Avila L, Vernos I, Akhtar A. An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Nature communications. 2015; 6: 7889. DOI 10.1038/ncomms8889
dc.identifier.citation	2041-1723
dc.identifier.citation	0021-9258
dc.identifier.citation	http://dx.doi.org/10.1038/ncomms8889
dc.identifier.uri	http://hdl.handle.net/10230/25113
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Nature Publishing Group
dc.relation	Nature communications. 2015; 6: 7889
dc.rights	© 2015 Macmillan Publishers Limited. All rights reserved. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/4.0/
dc.subject	Regulació genètica
dc.subject	Mitosi
dc.title	An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minus-end-binding protein, revealing a new class of mitosis-specific microtubule minus-end regulators. By adopting distinct functions in interphase and mitosis, KANSL proteins provide a link to coordinate the tasks of faithful expression and inheritance of the genome during different phases of the cell cycle.

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