dc.contributor.author |
Czachorowski, Maciej J |
dc.contributor.author |
Amaral, André F.S. |
dc.contributor.author |
Montes-Moreno, Santiago |
dc.contributor.author |
Lloreta Trull, Josep, 1958- |
dc.contributor.author |
Carrato, Alfredo |
dc.contributor.author |
Tardón, Adonina |
dc.contributor.author |
Morente, Manuel M |
dc.contributor.author |
Kogevinas, Manolis |
dc.contributor.author |
Real, Francisco X. |
dc.contributor.author |
Malats i Riera, Núria |
dc.date |
2012 |
dc.identifier.citation |
Czachorowski MJ, Amaral AFS, Montes-Moreno S, Lloreta J, Carrato A, Tardón A et al. Cyclooxygenase-2 expression in bladder cancer and patient prognosis: results from a large clinical cohort and meta-analysis. PLoS ONE. 2012; 7(9): e45025. DOI 10.1371/journal.pone.0045025 |
dc.identifier.citation |
1932-6203 |
dc.identifier.citation |
http://dx.doi.org/10.1371/journal.pone.0045025 |
dc.identifier.uri |
http://hdl.handle.net/10230/23558 |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Public Library of Science (PLoS) |
dc.relation |
PLoS ONE. 2012; 7(9): e45025 |
dc.relation |
info:eu-repo/grantAgreement/EC/FP6/37739 |
dc.relation |
info:eu-repo/grantAgreement/EC/FP7/201663 |
dc.relation |
info:eu-repo/grantAgreement/EC/FP7/201333 |
dc.rights |
© 2012 Czachorowski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Bufeta -- Càncer -- Etiologia -- Diferències entre sexes |
dc.title |
Cyclooxygenase-2 expression in bladder cancer and patient prognosis: results from a large clinical cohort and meta-analysis |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
Aberrant overexpression of cyclooxygenase-2 (COX2) is observed in urothelial carcinoma of the bladder (UCB). Studies evaluating COX2 as a prognostic marker in UCB report contradictory results. We determined the prognostic potential of COX2 expression in UCB and quantitatively summarize the results with those of the literature through a meta-analysis. Newly diagnosed UCB patients recruited between 1998–2001 in 18 Spanish hospitals were prospectively included in the study and followed-up (median, 70.7 months). Diagnostic slides were reviewed and uniformly classified by expert pathologists. Clinical data was retrieved from hospital charts. Tissue microarrays containing non-muscle invasive (n = 557) and muscle invasive (n = 216) tumours were analyzed by immunohistochemistry using quantitative image analysis. Expression was evaluated in Cox regression models to assess the risk of recurrence, progression and disease-specific mortality. Meta-hazard ratios were estimated using our results and those from 11 additional evaluable studies. COX2 expression was observed in 38% (211/557) of non-muscle invasive and 63% (137/216) of muscle invasive tumors. Expression was associated with advanced pathological stage and grade (p<0.0001). In the univariable analyses, COX2 expression - as a categorical variable - was not associated with any of the outcomes analyzed. As a continuous variable, a weak association with recurrence in non-muscle invasive tumors was observed (p-value = 0.048). In the multivariable analyses, COX2 expression did not independently predict any of the considered outcomes. The meta-analysis confirmed these results. We did not find evidence that COX2 expression is an independent prognostic marker of recurrence, progression or survival in patients with UCB. |
dc.description.abstract |
The work was partially supported by the Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Ministry of Science and Innovation, Spain (G03/174, 00/0745, PI051436, PI061614 and G03/174); Red Temática de Investigación Cooperativa en Cáncer- RD06/0020-RTICC; Consolider ONCOBIO; EU-FP6-STREP-37739-DRoP-ToP; EU-FP7-HEALTH-F2-2008-201663-UROMOL; EU-FP7-HEALTH-F2-2008-201333-DECanBio; USA-NIH-RO1-CA089715; and a PhD fellowship awarded to MJC from the ‘‘la Caixa’’ foundation, Spain, and a postdoctoral fellowship awarded to AFSA from the Fundación Científica de la AECC |