dc.contributor.author |
Mendez, Michelle A. |
dc.contributor.author |
García Esteban, Raquel |
dc.contributor.author |
Guxens, Mònica |
dc.contributor.author |
Vrijheid, Martine |
dc.contributor.author |
Kogevinas, Manolis |
dc.contributor.author |
Goñi, Fernando |
dc.contributor.author |
Fochs, Silvia |
dc.contributor.author |
Sunyer Deu, Jordi |
dc.date |
2011 |
dc.identifier.citation |
Mendez MA, Garcia-Esteban R, Guxens M, Vrijheid M, Kogevinas M, Goni F, Fochs S, Sunyer J. Prenatal organochlorine compound exposure, rapid weight gain, and overweight in infancy. Environmental Health Perspectives. 2011; 119(2): 272-278. DOI 10.1289/ehp.1002169 |
dc.identifier.citation |
0091-6765 |
dc.identifier.citation |
http://dx.doi.org/10.1289/ehp.1002169 |
dc.identifier.uri |
http://hdl.handle.net/10230/23354 |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
National Institute of Environmental Health Sciences (NIEHS) |
dc.relation |
Environmental Health Perspectives. 2011; 119(2): 272-278 |
dc.rights |
Reproduced with permission from Environmental Health Perspectives |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Infants -- Desenvolupament |
dc.subject |
Obesitat en els infants |
dc.subject |
β-hexachlorohexane |
dc.subject |
Body mass index |
dc.subject |
Dichlorodiphenyldichloroethylene |
dc.subject |
Hexachlorobenzene |
dc.subject |
Infant |
dc.subject |
Obesity |
dc.subject |
Polychlorinated biphenyls |
dc.subject |
Prenatal |
dc.subject |
Weight gain |
dc.title |
Prenatal organochlorine compound exposure, rapid weight gain, and overweight in infancy |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
Background: Although it has been hypothesized that fetal exposure to endocrine-disrupting chemicals may increase obesity risk, empirical data are limited, and it is uncertain how early in life any effects may begin. Objectives: We explored whether prenatal exposure to several organochlorine compounds (OCs) is associated with rapid growth in the first 6 months of life and body mass index (BMI) later in infancy. Methods: Data come from the INMA (Infancia y Medio-Ambiente) Child and Environment birth cohort in Spain, which recruited 657 women in early pregnancy. Rapid growth during the first 6 months was defined as a change in weight-for-age z-scores > 0.67, and elevated BMI at 14 months, as a z-score ≥ the 85th percentile. Generalized linear models were used to estimate the risk of rapid growth or elevated BMI associated with 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE), hexachlorobenzene, β-hexachlorohexane, and polychlorinated biphenyls in first-trimester maternal serum. Results: After multivariable adjustment including other OCs, DDE exposure above the first quartile was associated with doubling of the risk of rapid growth among children of normal-weight (BMI < 25 kg/m2), but not overweight, mothers. DDE was also associated with elevated BMI at 14 months (relative risk per unit increase in log DDE = 1.50; 95% confidence interval, 1.11–2.03). Other OCs were not associated with rapid growth or elevated BMI after adjustment. Conclusions: In this study we found prenatal DDE exposure to be associated with rapid weight gain in the first 6 months and elevated BMI later in infancy, among infants of normal-weight mothers. More research exploring the potential role of chemical exposures in early-onset obesity is needed. |
dc.description.abstract |
This work was supported by grants from the Spanish Ministry of Health (FIS-PI041436), Instituto de Salud Carlos III (Red INMA G03/176 and CB06/02/0041), the Generalitat de Catalunya-CIRIT (Consejo Interdepartamental de Investigación e Innovación Tecnológica) (1999SGR 00241), and the Fundació Roger Torner |