Binding of the transcription factor Atf1 to promoters serves as a barrier to phase nucleosome arrays and avoid cryptic transcription

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To access the full text documents, please follow this link: http://hdl.handle.net/10230/23351

dc.contributor.author	García, Patrícia
dc.contributor.author	Paulo Mirasol, Esther, 1984-
dc.contributor.author	Gao, Jun
dc.contributor.author	Wahls, Wayne P
dc.contributor.author	Ayté del Olmo, José
dc.contributor.author	Lowy Gallego, Ernesto
dc.contributor.author	Hidalgo Hernando, Elena
dc.date	2014
dc.identifier.citation	Garcia P, Paulo E, Gao J, Wahls WP, Ayté J, Lowy E, Hidalgo E. Binding of the transcription factor Atf1 to promoters serves as a barrier to phase nucleosome arrays and avoid cryptic transcription. Nucleic Acids Research. 2014; 42(16): 10351-10359. DOI 10.1093/nar/gku704
dc.identifier.citation	0305-1048
dc.identifier.citation	http://dx.doi.org/10.1093/nar/gku704
dc.identifier.uri	http://hdl.handle.net/10230/23351
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Oxford University Press
dc.relation	Nucleic Acids Research. 2014; 42(16): 10351-10359
dc.relation	info:eu-repo/grantAgreement/ES/3PN/BFU2012-32045
dc.rights	© Garcia P, Paulo E, Gao J, Wahls WP, Ayté J, Lowy E, Hidalgo E [2014]. Published by Oxford University Press. This is an Open Access article distributed under the terms of a Creative Commons Attribution License
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/4.0/
dc.subject	Estrès oxidatiu
dc.subject	Schizosaccharomyces pombe -- Metabolisme
dc.title	Binding of the transcription factor Atf1 to promoters serves as a barrier to phase nucleosome arrays and avoid cryptic transcription
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Schizosaccharomyces pombe displays a large transcriptional response common to several stress conditions, regulated primarily by the transcription factor Atf1. Atf1-dependent promoters contain especially broad nucleosome depleted regions (NDRs) prior to stress imposition. We show here that basal binding of Atf1 to these promoters competes with histones to create wider NDRs at stress genes. Moreover, deletion of atf1 results in nucleosome disorganization specifically at stress coding regions and derepresses antisense transcription. Our data indicate that the transcription factor binding to promoters acts as an effective barrier to fix the +1 nucleosome and phase downstream nucleosome arrays to prevent cryptic transcription.
dc.description.abstract	Spanish Ministry of Science and Innovation [BFU2012-32045]; PLAN E and FEDER; Generalitat de Catalunya (Spain) [SGR2009-195 to E.H.]; ICREA Academia Awards (Generalitat de Catalunya) [to J.A. and E.H.]; Juan de la Cierva from the Spanish Ministry of Science and Innovation[toP.G.]. Funding for open access charge: Spanish Ministry of Science and Innovation [BFU2012-32045]; PLAN E and FEDER; Generalitat de Catalunya (Spain) [SGR2009-195 to E.H.]

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