Non-linear formation of EtG and FAEEs after controlled administration of low to moderate doses of ethanol

Home | About RECERCAT | Contact

Català | Castellano

All of RECERCAT

By Communities &
Collections By Defense Date By Authors By Titles By Subject

This Collection

By Defense Date By Authors By Titles By Subject

Statistics

View Statistics All RECERCAT

My RECERCAT

Other repositories directory

RECERCAT Home > Universitat Pompeu Fabra > Articles, congressos, llibres > View document

To access the full text documents, please follow this link: http://hdl.handle.net/10230/34215

dc.contributor.author	Pérez Mañá, Clara
dc.contributor.author	Farré Albaladejo, Magí
dc.contributor.author	Pastor, Antonio
dc.contributor.author	Fonseca Casals, Francina, 1972-
dc.contributor.author	Torrens, Marta
dc.contributor.author	Menoyo Colomer, Esther
dc.contributor.author	Pujadas Bastardes, Mitona
dc.contributor.author	Frias, Silvia
dc.contributor.author	Langohr, Klaus
dc.contributor.author	Torre Fornell, Rafael de la
dc.date	2017
dc.identifier.citation	Pérez-Mañá C, Farré M, Pastor A, Fonseca F, Torrens M, Menoyo E. et al. Non-Linear Formation of EtG and FAEEs after Controlled Administration of Low to Moderate Doses of Ethanol. Alcohol Alcohol. 2017 Sep 1;52(5):587-594. DOI: 10.1093/alcalc/agx033
dc.identifier.citation	0735-0414
dc.identifier.citation	http://dx.doi.org/10.1093/alcalc/agx033
dc.identifier.uri	http://hdl.handle.net/10230/34215
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Oxford University Press
dc.relation	Alcohol Alcohol. 2017 Sep 1;52(5):587-594
dc.relation	info:eu-repo/grantAgreement/EC/2018-09-31
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.rights	© Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Alcohol and alcoholism following peer review. The definitive publisher-authenticated version Pérez-Mañá C, Farré M, Pastor A, Fonseca F, Torrens M, Menoyo E. et al. Non-Linear Formation of EtG and FAEEs after Controlled Administration of Low to Moderate Doses of Ethanol. Alcohol Alcohol. 2017 Sep 1;52(5):587-594 is available online at: http://dx.doi.org/10.1093/alcalc/agx033
dc.subject	Marcadors bioquímics
dc.subject	Alcohol -- Efectes fisiològics
dc.subject	Ethanol
dc.subject	Esters
dc.title	Non-linear formation of EtG and FAEEs after controlled administration of low to moderate doses of ethanol
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion
dc.description.abstract	AIMS: Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) are non-oxidative metabolites of alcohol that can be detected in conventional and non-conventional biological matrices for longer periods than alcohol. The aim was to describe the time courses of both biomarkers after ingestion of acute low-moderate doses of ethanol. METHODS: The study design was double-blind, randomized, crossover and controlled with placebo. Participants were distributed in three different cohorts: (a) Cohort-1: two doses of 18 and 30 g of ethanol and placebo were administered to 12 subjects; (b) Cohort-2: two doses of 6 and 12 g of ethanol and placebo were administered to six subjects and (c) Cohort-3: two doses of 24 and 42 g of ethanol and placebo were administered to six subjects. Each participant received two doses of ethanol and placebo. Plasma concentrations (0-6 h) of ethanol and specific FAEEs (palmitic, stearic, linoleic and oleic acid ethyl esters) and urinary concentrations of EtG (0-24 h) were measured. RESULTS: A dose-dependent increase in blood ethanol concentrations was observed. EtG excretion and FAEEs plasmatic concentrations showed a disproportionate increase with the ethanol dose suggesting non-linearity. Area under the curve (AUC0-6h) of ethanol concentrations showed a linear trend with non-oxidative metabolites' concentrations. CONCLUSION: The formation rate of ethanol non-oxidative biomarkers does not follow a linear trend, explained mainly by a disproportionate increase in AUC0-6h of ethanol concentrations in relation to dose. This observation should be taken into account when interpreting results in biological matrices in clinical and forensic settings. SHORT SUMMARY: A double-blind, randomized, crossover and controlled study was conducted administering ethanol (6-42 g). Ethyl glucuronide (EtG) excretion and fatty acid ethyl esters (FAEEs) plasmatic concentrations showed a disproportionate increase with the ethanol dose suggesting non-linearity. This observation should be taken into account when interpreting biomarker concentrations in clinical settings.

Show simple item record

All of RECERCAT

This Collection

Statistics

My RECERCAT

Related documents

Other documents of the same author