Long non-coding RNAs as a source of new peptides

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dc.contributor.author	Ruiz Orera, Jorge, 1988-
dc.contributor.author	Messeguer, Xavier
dc.contributor.author	Subirana, Juan A.
dc.contributor.author	Albà Soler, Mar
dc.date	2014
dc.identifier.citation	Ruiz-Orera J, Messeguer X, Subirana JA, Alba MM. Long non-coding RNAs as a source of new peptides. Elife. 2014 Sep 16; 3: e03523. doi: 10.7554/eLife.03523
dc.identifier.citation	2050-084X
dc.identifier.citation	http://dx.doi.org/10.7554/eLife.03523
dc.identifier.uri	http://hdl.handle.net/10230/32245
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	eLife
dc.relation	info:eu-repo/grantAgreement/ES/1PE/BFU2012-36820
dc.relation	info:eu-repo/grantAgreement/ES/1PE/TIN2013-45732-C4-3-P
dc.rights	© Jorge Ruiz-Orera et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited
dc.rights	https://creativecommons.org/licenses/by/4.0/
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	RNA no missatgers
dc.subject	Pèptids
dc.subject	Proteïnes -- Síntesi
dc.subject	Genètica
dc.title	Long non-coding RNAs as a source of new peptides
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Deep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames (ORFs) and which have been termed long non-coding RNAs (lncRNAs). The vast majority of lncRNAs are lineage-specific and do not yet have a known function. In this study, we test the hypothesis that they may act as a repository for the synthesis of new peptides. We find that a large fraction of the lncRNAs expressed in cells from six different species is associated with ribosomes. The patterns of ribosome protection are consistent with the translation of short peptides. lncRNAs show similar coding potential and sequence constraints than evolutionary young protein coding sequences, indicating that they play an important role in de novo protein evolution
dc.description.abstract	This work was funded by Ministerio de Economía y Competitividad (BFU2012-36820 and TIN2013-45732-C4-3-P) and Fundació ICREA (MMA)

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