Autophagy: a decisive process for stemness

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dc.contributor.author	García Prat, Laura
dc.contributor.author	Martínez Vicente, Marta
dc.contributor.author	Muñoz Cánoves, Pura, 1962-
dc.date	2016
dc.identifier.citation	García-Prat L, Martínez-Vicente M, Muñoz-Cánoves P. Autophagy: a decisive process for stemness. Oncotarget. 2016; 7(11): 12286-12288. DOI 10.18632/oncotarget.7766
dc.identifier.citation	1949-2553
dc.identifier.citation	http://dx.doi.org/10.18632/oncotarget.7766
dc.identifier.uri	http://hdl.handle.net/10230/26920
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Impact Journals
dc.relation	Oncotarget. 2016; 7(11): 12286-1228
dc.relation	info:eu-repo/grantAgreement/ES/3PN/SAF2012-38547
dc.relation	info:eu-repo/grantAgreement/ES/1PE/SAF2015-67369-R
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	Published originally by Impact Journals at http://dx.doi.org/10.18632/oncotarget.7766 under a Creative Commons Attribution 3.0 License.
dc.rights	http://creativecommons.org/licenses/by/3.0/
dc.subject	Músculs -- Envelliment
dc.subject	Aging
dc.subject	Autophagy
dc.subject	Muscle
dc.subject	Senescence
dc.subject	Stem cells
dc.title	Autophagy: a decisive process for stemness
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective "clean-up" system is lost during aging, resulting in stem cell regenerative decline. Thus, autophagy is required for muscle stem cell homeostasis maintenance.
dc.description.abstract	Work in the authors’ laboratories has been supported by: MINECO, Spain SAF2012-38547, SAF2015-67369-R, AFM, E-Rare/Eranet, Fundació Marató-TV3, MDA, EU-FP7 (Myoage, Optistem and Endostem) and DuchennePP-NL, to PM-C; and ISCIII, Spain (FISPS09/01267, FIS-PI13/02512, CP09/00184, PI14/01529) and CIBERNED to MM-V. L.G.-P. was supported by a Predoctoral Fellowship from Programa de Formación de Personal Investigador (Spain).

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