Centres de Recerca de Catalunya (CERCA)
Now showing items 1-11 of 11
We introduce a hybrid two-dimensional multiscale model of angiogenesis, the process by which endothelial cells (ECs) migrate from a pre-existing vascular bed in response to local environmental cues and cell-cell interactions, ...
Correction to: Nature Communications https://doi.org/10.1038/s41467-020-14824-w, published online 26 February 2020. The original version of the Supplementary Information file associated with this Article contained several ...
Tumour cell heterogeneity is a major barrier for efficient design of targeted anti-cancer therapies. A diverse distribution of phenotypically distinct tumour-cell subpopulations prior to drug treatment predisposes to ...
In this work, we have investigated the evolutionary dynamics of a generalist pathogen, e.g., a virus population, that evolves toward specialization in an environment with multiple host types. We have particularly explored ...
Environmental conditions can affect viral accumulation, virulence and adaptation, which have implications in the disease outcomes and efficiency of control measures. Concurrently, mixed viral infections are relevant in ...
A fundamental aim of post-genomic 21st century biology is to understand the genotype–phenotype map (GPM) or how specific genetic variation relates to specific phenotypic variation. Quantitative genetics approximates such ...
How does morphological complexity evolve? This study suggests that the likelihood of mutations increasing phenotypic complexity becomes smaller when the phenotype itself is complex. In addition, the complexity of the ...
BACKGROUND: Plasmids are mobile genetic elements that often carry accessory genes, and are vectors for horizontal transfer between bacterial genomes. Plasmid detection in large genomic datasets is crucial to analyze their ...
Background: Genital warts are a common and highly contagious sexually transmitted disease. They have a large economic burden and affect several aspects of quality of life. Incidence data underestimate the real occurrence ...
We study the basic reproduction number (R0) in an epidemic model where infected individuals are initially asymptomatic and structured by the time since infection. At the beginning of an epidemic outbreak the computation ...
What is the potential for synthetic biology as a way of engineering, on a large scale, complex ecosystems? Can it be used to change endangered ecological communities and rescue them to prevent their collapse? What are the ...
