Target-guided synthesis of metal-based phosphatase inhibitors

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RECERCAT Home > Generalitat de Catalunya > Agència de Gestió d'Ajuts Universitaris i de Recerca > Beques i ajuts de recerca a investigadors postdoctorals > View document

Use this identifier to quote or link this document: http://hdl.handle.net/2072/179683

dc.contributor	Agència de Gestió d'Ajuts Universitaris i de Recerca
dc.contributor	Imperial College London
dc.contributor.author	Angurell Purroy, Inmaculada
dc.date.accessioned	2012-02-10T10:25:11Z
dc.date.available	2012-02-10T10:25:11Z
dc.date.created	2008
dc.date.issued	2012-02-10
dc.identifier.uri	http://hdl.handle.net/2072/179683
dc.format.extent	8 p.
dc.language.iso	cat
dc.relation.ispartofseries	Els ajuts de l'AGAUR;2006 BP-A10030
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.source	RECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.other	Fosfatases
dc.subject.other	Antienzims
dc.title	Target-guided synthesis of metal-based phosphatase inhibitors
dc.type	info:eu-repo/semantics/other
dc.subject.udc	546 - Química inorgànica
dc.embargo.terms	cap
dc.description.abstract	Report for the scientific sojourn at the Imperial College of London, United Kingdom, from 2007 to 2009. PTEN is a tumour suppressor enzyme that plays important roles in the PI3K pathway which regulates growth, proliferation and survival and is thus related to many human disorders such as diabetes, neurodegenerative diseases, cardiovascular complications and cancer. It is hence of great interest to understand in detail its molecular behaviour and to find small molecules that can switch on/off its activity. For this purpose, metal complexes have been synthesized and preliminary studies in vivo show that all are capable of inhibiting PTEN.

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