dc.contributor
Agència de Gestió d'Ajuts Universitaris i de Recerca
dc.contributor
Imperial College London
dc.contributor.author
Angurell Purroy, Inmaculada
dc.date.accessioned
2012-02-10T10:25:11Z
dc.date.available
2012-02-10T10:25:11Z
dc.date.issued
2012-02-10
dc.identifier.uri
http://hdl.handle.net/2072/179683
dc.description.abstract
Report for the scientific sojourn at the Imperial College of London, United Kingdom, from 2007 to 2009. PTEN is a tumour suppressor enzyme that plays important roles in the PI3K pathway which regulates growth, proliferation and survival and is thus related to many human disorders such as diabetes, neurodegenerative diseases, cardiovascular complications and cancer. It is hence of great interest to understand in detail its molecular behaviour and to find small molecules that can switch on/off its activity. For this purpose, metal complexes have been synthesized and preliminary studies in vivo show that all are capable of inhibiting PTEN.
eng
dc.format.extent
8 p.
cat
dc.relation.ispartofseries
Els ajuts de l'AGAUR;2006 BP-A10030
dc.rights
info:eu-repo/semantics/openAccess
dc.rights
L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.source
RECERCAT (Dipòsit de la Recerca de Catalunya)
dc.subject.other
Fosfatases
cat
dc.subject.other
Antienzims
cat
dc.title
Target-guided synthesis of metal-based phosphatase inhibitors
cat
dc.type
info:eu-repo/semantics/other
cat
