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Títol:	Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods
Autor/a:	Fernández-Yagüe, Marc; Pérez Antoñanzas, Roman; Roa, Joan Josep; Biggs, Manus; Gil Mur, Francisco Javier; Pegueroles Neyra, Marta
Notes:	Biomimetic design is a key tenet of orthopedic device technology, and in particular the development of responsive surfaces that promote ion exchange with interfacing tissues, facilitating the ionic events that occur naturally during bone repair, hold promise in orthopedic fixation strategies. Non-bioactive nanostructured titanium implants treated by shot-blasting and acid-etching (AE) induced higher bone implant contact (BIC=52% and 65%) compared to shot-blasted treated (SB) implants (BIC=46% and 47%) at weeks 4 and 8, respectively. However, bioactive charged implants produced by plasma (PL) or thermochemical (BIO) processes exhibited enhanced osteoconductivity through specific ionic surface-tissue exchange (PL, BIC= 69% and 77% and BIO, BIC= 85% and 87% at weeks 4 and 8 respectively). Furthermore, bioactive surfaces (PL and BIO) showed functional mechanical stability (resonance frequency analyses) as early as 4 weeks post implantation via increased total bone area (BAT=56% and 59%) ingrowth compared to SB (BAT=35%) and AE (BAT=35%) surfaces.
Matèries:	-Titani -Funcionalització -Topografies -Reparació òssia -Càrregues elèctriques -Titanio -Funcionalización -Topografías -Reparación ósea -Cargas eléctricas -Titanium -Functionalization -Topographies -Bone repair -Electrical charges -61 -616.3
Drets:	© 2021 Elsevier B.V. or its licensors or contributors. ScienceDirect ® is a registered trademark of Elsevier B.V.
Tipus de document:	Article Article - Versió acceptada
Publicat per:	Elsevier
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