To access the full text documents, please follow this link: http://hdl.handle.net/20.500.12328/1991
dc.contributor.author | Izquierdo, Conchita |
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dc.contributor.author | Ciruela, Pilar |
dc.contributor.author | Hernández, Sergi |
dc.contributor.author | García-García, Juan José |
dc.contributor.author | Esteva, Cristina |
dc.contributor.author | Moraga-Llop, Fernando |
dc.contributor.author | Díaz-Conradi, A. |
dc.contributor.author | Martínez-Osorio, Johanna |
dc.contributor.author | Solé-Ribalta, Anna |
dc.contributor.author | De Sevilla, Mariona F. |
dc.contributor.author | González-Peris, Sebastià |
dc.contributor.author | Codina, Gemma |
dc.contributor.author | Planes, Ana María |
dc.contributor.author | Uriona, Sonia |
dc.contributor.author | Campins, Magda |
dc.contributor.author | Muñoz-Almagro, Carmen |
dc.contributor.author | Salleras, Luis |
dc.contributor.author | Domínguez, Ángela |
dc.date | 2021-02-12T13:26:37Z |
dc.date | 2021-02-12T13:26:37Z |
dc.date | 2020-11 |
dc.identifier | Izquierdo, C.; Ciruela, P.; Hernández, S. [et al.]. Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era. Epidemiology and Infection, 2020, 148, e279. Disponible en: <https://www.cambridge.org/core/journals/epidemiology-and-infection/article/pneumococcal-serotypes-in-children-clinical-presentation-and-antimicrobial-susceptibility-in-the-pcv13-era/AE1B808500024D32F81D250C12155339#>. Fecha de acceso: 12 feb. 2021. DOI: 10.1017/ S0950268820002708 |
dc.identifier | 0950-2688 |
dc.identifier | http://hdl.handle.net/20.500.12328/1991 |
dc.identifier | https://doi.org/10.1017/ S0950268820002708 |
dc.identifier.uri | http://hdl.handle.net/20.500.12328/1991 |
dc.description | The aim was to analyse invasive pneumococcal disease (IPD) serotypes in children aged ⩽17 years according to clinical presentation and antimicrobial susceptibility. We conducted a prospective study (January 2012–June 2016). IPD cases were diagnosed by culture and/or real-time polymerase chain reaction (PCR). Demographic, microbiological and clinical data were analysed. Associations were assessed using the odds ratio (OR) and 95% confidence intervals (CI). Of the 253 cases, 34.4% were aged <2 years, 38.7% 2–4 years and 26.9% 5–17 years. Over 64% were 13-valent pneumococcal conjugate vaccine (PCV13) serotypes. 48% of the cases were diagnosed only by real-time PCR. Serotypes 3 and 1 were associated with complicated pneumonia (P < 0.05) and non-PCV13 serotypes with meningitis (OR 7.32, 95% CI 2.33–22.99) and occult bacteraemia (OR 3.6, 95% CI 1.56–8.76). Serotype 19A was more frequent in children aged <2 years and serotypes 3 and 1 in children aged 2–4 years and 5–17 years, respectively. 36.1% of cases were not susceptible to penicillin and 16.4% were also non-susceptible to cefotaxime. Serotypes 14, 24F and 23B were associated with non-susceptibility to penicillin (P < 0.05) and serotypes 11, 14 and 19A to cefotaxime (P < 0.05). Serotype 19A showed resistance to penicillin (P = 0.002). In conclusion, PCV13 serotypes were most frequent in children aged ⩽17 years, mainly serotypes 3, 1 and 19A. Non-PCV13 serotypes were associated with meningitis and occult bacteraemia and PCV13 serotypes with pneumonia. Non-susceptibility to antibiotics of non-PCV13 serotypes should be monitored. |
dc.format | 12 |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | Cambridge University Press |
dc.relation | Epidemiology and Infection |
dc.relation | 148; |
dc.rights | © The Author(s), 2020. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
dc.rights | http://creativecommons.org/licenses/by/4.0/ |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Infants -- Salut i higiene |
dc.subject | Pneumococs |
dc.subject | Vacunes |
dc.subject | Penicil·lina |
dc.subject | Niños -- Salud e Higiene |
dc.subject | Streptococcus pneumoniae |
dc.subject | Vacunas |
dc.subject | Penicilina |
dc.subject | Children -- Health and hygiene |
dc.subject | Pneumococcus |
dc.subject | Vaccines |
dc.subject | Penicillin |
dc.subject | 61 |
dc.title | Pneumococcal serotypes in children, clinical presentation and antimicrobial susceptibility in the PCV13 era |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |