Surface immobilization and bioactivity of TGF-ß1 inhibitor peptides for bone implant applications

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To access the full text documents, please follow this link: http://hdl.handle.net/20.500.12328/1520

dc.contributor.author	Sevilla Sánchez, Pablo
dc.contributor.author	Vining, Kyle V.
dc.contributor.author	Dotor de las Herrerias, Javier
dc.contributor.author	Rodríguez Rius, Daniel
dc.contributor.author	Gil Mur, Francisco Javier
dc.contributor.author	Aparicio Bádenas, Conrado José
dc.date	2020-05-11T15:27:14Z
dc.date	2020-05-11T15:27:14Z
dc.date	2016-02-01
dc.identifier	Sevilla Sánchez, Pablo; Vining, Kyle V.; Dotor de las Herrerias, Javier [et al.]. Surface immobilization and bioactivity of TGF-ß1 inhibitor peptides for bone implant applications. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2016, 104(2), p. 385-394. Disponible en: <https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.33374>. Fecha de acceso: 11 may. 2020. DOI: 10.1002/jbm.b.33374
dc.identifier	1552-4981
dc.identifier	http://dx.doi.org/10.1002/jbm.b.33374
dc.identifier.uri	http://hdl.handle.net/20.500.12328/1520
dc.description	TGF-ß1 is the most related cytokine with the production of fibrotic tissue. It plays an important role on the production of collagen by fibroblasts and other types of cells. The inhibition of this cytokine reduces fibrosis in various types of tissue. Biofunctionalization of dental and orthopedic implants with biomolecules enables modification of the physical, chemical and biochemical properties of their surfaces to improve its biological and clinical performance. Our objective was to develop a reliable method to immobilize oligopeptides on Ti surfaces to obtain a surface with TGF-ß1 inhibitory activity that will potentially minimize fibrotic encapsulation of implants during the process of osseointegration. We covalently immobilized TGF-ß1 inhibitor P17-peptides on Ti surfaces and assessed by characterizing each step of the process that we successfully biofunctionalized the implant surfaces. High amounts of peptides were anchored and homogeneously distributed on the surfaces with mechanical and thermochemical stability after in vitro simulated challenges. Notably, the immobilized peptides retained their TGF-ß1 inhibitory activity in vitro. Thus, these biofunctional coatings are potential candidates for inducing a fast and reliable osseointegration in vivo.
dc.format	30
dc.format	application/pdf
dc.language	eng
dc.publisher	Wiley
dc.relation	Journal of Biomedical Materials Research Part B: Applied Biomaterials
dc.relation	104;2
dc.relation	info:eu-repo/grantAgreement/MINECO/6PN/MAT2012-30706
dc.rights	© 2016 John Wiley & Sons, Inc.
dc.subject	Materials biomèdics
dc.subject	Superfícies
dc.subject	Pèptids -- Inhibidors
dc.subject	Titani
dc.subject	Implants artificiales
dc.subject	Ossos
dc.subject	Materiales biomédicos
dc.subject	Superficies
dc.subject	Péptidos -- Inhibidores
dc.subject	Titanio
dc.subject	Implantes artificiales
dc.subject	Huesos
dc.subject	Biomedical materials
dc.subject	Surfaces
dc.subject	Peptides -- Inhibitors
dc.subject	Titanium
dc.subject	Artificial implants
dc.subject	Bones
dc.subject	62
dc.title	Surface immobilization and bioactivity of TGF-ß1 inhibitor peptides for bone implant applications
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion

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