dc.contributor
Institut Català de la Salut
dc.contributor
[Adukauskiene D, Ciginskiene A] Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. [Adukauskaite A] Department of Cardiology and Angiology, University Hospital of Innsbruck, Innsbruck, Austria. [Koulenti D] Second Critical Care Department, Attikon University Hospital, Athens, Greece. UQ Centre for Clinical Research (UQCCR), Faculty of Medicine, The Univesrity of Queensland, Brisbane, Australia. [Rello J] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Clinical Research, CHU Nîmes, Nîmes, France
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Adukauskienė, Dalia
dc.contributor.author
Čiginskienė, Aušra
dc.contributor.author
Adukauskaite, Agne
dc.contributor.author
Koulenti, Despoina
dc.contributor.author
Rello, Jordi
dc.date.accessioned
2025-10-24T08:48:56Z
dc.date.available
2025-10-24T08:48:56Z
dc.date.issued
2023-07-03T07:52:53Z
dc.date.issued
2023-07-03T07:52:53Z
dc.date.issued
2023-06-15
dc.identifier
Adukauskiene D, Ciginskiene A, Adukauskaite A, Koulenti D, Rello J. Clinical Features and Outcomes of VAP Due to Multidrug-Resistant Klebsiella spp.: A Retrospective Study Comparing Monobacterial and Polybacterial Episodes. Antibiotics. 2023 Jun 15;12(6):1056.
dc.identifier
https://hdl.handle.net/11351/9944
dc.identifier
10.3390/antibiotics12061056
dc.identifier.uri
http://hdl.handle.net/11351/9944
dc.description.abstract
Klebsiella; Aspiration pneumonia; Multidrug-resistance
dc.description.abstract
Klebsiella; Neumonía por aspiración; Resistencia a múltiples fármacos
dc.description.abstract
Klebsiella; Pneumònia per aspiració; Resistència a múltiples fàrmacs
dc.description.abstract
VAP due to multidrug-resistant (MDR) bacteria is a frequent infection among patients in ICUs. Patient characteristics and mortality in mono- and polybacterial cases of VAP may differ. A single-centre, retrospective 3-year study was conducted in the four ICUs of a Lithuanian referral university hospital, aiming to compare both the clinical features and the 60-day ICU all-cause mortality of monobacterial and polybacterial MDR Klebsiella spp. VAP episodes. Of the 86 MDR Klebsiella spp. VAP episodes analyzed, 50 (58.1%) were polybacterial. The 60-day mortality was higher (p < 0.05) in polybacterial episodes: overall (50.0 vs. 27.8%), in the sub-group with less-severe disease (SOFA < 8) at VAP onset (45.5 vs. 15.0%), even with appropriate treatment (41.7 vs. 12.5%), and the sub-group of extended drug-resistant (XDR) Klebsiella spp. (46.4 vs. 17.6%). The ICU mortality (44.0 vs. 22.5%) was also higher in the polybacterial episodes. The monobacterial MDR Klebsiella spp. VAP was associated (p < 0.05) with prior hospitalization (61.1 vs. 40.0%), diabetes mellitus (30.6 vs. 5.8%), obesity (30.6 vs. 4.7%), prior antibiotic therapy (77.8 vs. 52.0%), prior treatment with cephalosporins (66.7 vs. 36.0%), and SOFA cardiovascular ≥ 3 (44.4 vs. 10.0%) at VAP onset. Patients with polybacterial VAP were more likely (p < 0.05) to be comatose (22.2 vs. 52.0%) and had a higher SAPS II score (median [IQR] 45.0 [35.25–51.1] vs. 50.0 [40.5–60.75]) at VAP onset. Polybacterial MDR Klebsiella spp. VAP had distinct demographic and clinical characteristics compared to monobacterial, and was associated with poorer outcomes.
dc.format
application/pdf
dc.relation
Antibiotics;12(6)
dc.relation
https://doi.org/10.3390/antibiotics12061056
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Pneumònia - Tractament
dc.subject
Resistència als medicaments
dc.subject
Respiració artificial - Complicacions
dc.subject
Infeccions nosocomials
dc.subject
DISEASES::Bacterial Infections and Mycoses::Infection::Cross Infection::Pneumonia, Ventilator-Associated
dc.subject
PHENOMENA AND PROCESSES::Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Multiple
dc.subject
DISEASES::Bacterial Infections and Mycoses::Infection::Cross Infection
dc.subject
ENFERMEDADES::infecciones bacterianas y micosis::infección::infección hospitalaria::neumonía asociada al ventilador
dc.subject
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::resistencia a medicamentos::resistencia múltiple a medicamentos
dc.subject
ENFERMEDADES::infecciones bacterianas y micosis::infección::infección hospitalaria
dc.title
Clinical Features and Outcomes of VAP Due to Multidrug-Resistant Klebsiella spp.: A Retrospective Study Comparing Monobacterial and Polybacterial Episodes
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
