dc.contributor
Institut Català de la Salut
dc.contributor
[Ramos H, Hernández C, Simó R, Simó-Servat O] Grup de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ICSIII), Madrid, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Ramos Abellán, Hugo
dc.contributor.author
Hernandez, Cristina
dc.contributor.author
Simó Canonge, Rafael
dc.contributor.author
Simó-Servat, Olga
dc.date.accessioned
2025-10-24T08:49:08Z
dc.date.available
2025-10-24T08:49:08Z
dc.date.issued
2023-06-12T08:04:16Z
dc.date.issued
2023-06-12T08:04:16Z
dc.date.issued
2023-05-15
dc.identifier
Ramos H, Hernández C, Simó R, Simó-Servat O. Inflammation: The Link between Neural and Vascular Impairment in the Diabetic Retina and Therapeutic Implications. Int J Mol Sci. 2023 May 15;24(10):8796.
dc.identifier
https://hdl.handle.net/11351/9714
dc.identifier
10.3390/ijms24108796
dc.identifier.uri
http://hdl.handle.net/11351/9714
dc.description.abstract
Diabetic retinopathy; Inflammation; Retina
dc.description.abstract
Retinopatia diabètica; Inflamació; Retina
dc.description.abstract
Retinopatía diabética; Inflamación; Retina
dc.description.abstract
The etiology of diabetic retinopathy (DR) is complex, multifactorial and compromises all the elements of the retinal neurovascular unit (NVU). This diabetic complication has a chronic low-grade inflammatory component involving multiple inflammatory mediators and adhesion molecules. The diabetic milieu promotes reactive gliosis, pro-inflammatory cytokine production and leukocyte recruitment, which contribute to the disruption of the blood retinal barrier. The understanding and the continuous research of the mechanisms behind the strong inflammatory component of the disease allows the design of new therapeutic strategies to address this unmet medical need. In this context, the aim of this review article is to recapitulate the latest research on the role of inflammation in DR and to discuss the efficacy of currently administered anti-inflammatory treatments and those still under development.
dc.description.abstract
This study has been funded by Instituto de Salud Carlos III (ISCIII) through the projects ICI20/00129 and PI22/01670 and co-funded by the European Union. Hugo Ramos is the recipient of a grant from the Ministerio de Economía y Competitividad (BES-2017-081690).
dc.format
application/pdf
dc.relation
International Journal of Molecular Sciences;24(10)
dc.relation
https://doi.org/10.3390/ijms24108796
dc.relation
info:eu-repo/grantAgreement/ES/PEICTI2021-2023/PI22%2F01670
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Retinopatia diabètica
dc.subject
Antiinflamatoris - Ús terapèutic
dc.subject
DISEASES::Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Angiopathies::Diabetic Retinopathy
dc.subject
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agents
dc.subject
ENFERMEDADES::enfermedades del sistema endocrino::diabetes mellitus::complicaciones de la diabetes::angiopatías diabéticas::retinopatía diabética
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinflamatorios
dc.title
Inflammation: The Link between Neural and Vascular Impairment in the Diabetic Retina and Therapeutic Implications
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
