Sistema de Salut de Catalunya
Institut Català de la Salut
[Martínez RJG] Clinical Analysis Department, Marqués de Valdecilla University Hospital, Santander, Spain. Evidence-Based Laboratory Medicine Commission, Spanish Society of Laboratory Medicine (SEQCML), Barcelona, Spain. [Gea CS, Martin-Riera V, Ruiz ARG, Barzanti RP, Ferrer-Costa R, Ramirez-Serra C] Grup de Recerca de Bioquímica Clínica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Bioquímica Clínica, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
2023-05-10T06:47:20Z
2023-05-10T06:47:20Z
2023-04-18
Dasatinib; Pleural effusion chylothorax
Dasatinib; Derrame pleural quilotórax
Dasatinib; Vessament pleural quilotòrax
Dasatinib is a tyrosine kinase inhibitor drug used for chronic myeloid leukaemia (CML) treatment. Chylothorax has been rarely reported as a secondary effect of dasatinib occurring especially in long-term treated patients, although its pathophysiology is not yet fully understood. Laboratory analysis of the pleural effusion is crucial for chylothorax diagnosis. We report a case of a 53-year-old male patient presenting a chylothorax after 14 years of dasatinib therapy where the clinical laboratory was key in the diagnosis.
Article
Published version
English
Proteïnes quinases - Inhibidors - Efectes secundaris; Embassament pleural; CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors; Other subheadings::Other subheadings::Other subheadings::/adverse effects; DISEASES::Respiratory Tract Diseases::Pleural Diseases::Chylothorax; Other subheadings::Other subheadings::Other subheadings::/chemically induced; COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::inhibidores enzimáticos::inhibidores de proteínas cinasas; Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos; ENFERMEDADES::enfermedades respiratorias::enfermedades pleurales::quilotórax; Otros calificadores::Otros calificadores::Otros calificadores::/inducido químicamente
International Federation of Clinical Chemistry and Laboratory Medicine
EJIFCC;34(1)
https://cms.ifcc.org/wp-content/uploads/2023/04/eJIFCC2023Vol34No1pp076-080.pdf
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
Articles científics - VHIR [1665]
