dc.contributor
Institut Català de la Salut
dc.contributor
[Sánchez-Maldonado JM, Cabrera-Serrano AJ] Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS, Granada, Spain. [Chattopadhyay S] Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany. Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany. [Campa D] Department of Biology, University of Pisa, Pisa, Italy. [Garrido MDP] Hematology Department, Virgen de las Nieves University Hospital, Granada, Spain. [Macauda A] Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. [Jerez A] Experimental Hematology Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Sánchez Maldonado, Jose Manuel
dc.contributor.author
Cabrera Serrano, Antonio José
dc.contributor.author
Chattopadhyay, Subhayan
dc.contributor.author
CAMPA, DANIELE
dc.contributor.author
Garrido , María del Pilar
dc.contributor.author
Macauda, Angelica
dc.contributor.author
Jerez, Andres
dc.date.accessioned
2025-10-25T05:36:53Z
dc.date.available
2025-10-25T05:36:53Z
dc.date.issued
2023-05-05T12:53:29Z
dc.date.issued
2023-05-05T12:53:29Z
dc.date.issued
2023-03-23
dc.identifier
Sánchez-Maldonado JM, Cabrera-Serrano AJ, Chattopadhyay S, Campa D, Garrido MDP, Macauda A, et al. GWAS-Identified Variants for Obesity Do Not Influence the Risk of Developing Multiple Myeloma: A Population-Based Study and Meta-Analysis. Int J Mol Sci. 2023 Mar 23;24(7):6029.
dc.identifier
https://hdl.handle.net/11351/9466
dc.identifier
10.3390/ijms24076029
dc.identifier.uri
http://hdl.handle.net/11351/9466
dc.description.abstract
Genetic variants; Multiple myeloma; Obesity
dc.description.abstract
Variantes genéticas; Mieloma múltiple; Obesidad
dc.description.abstract
Variants genètiques; Mieloma múltiple; Obesitat
dc.description.abstract
Multiple myeloma (MM) is an incurable disease characterized by the presence of malignant plasma cells in the bone marrow that secrete specific monoclonal immunoglobulins into the blood. Obesity has been associated with the risk of developing solid and hematological cancers, but its role as a risk factor for MM needs to be further explored. Here, we evaluated whether 32 genome-wide association study (GWAS)-identified variants for obesity were associated with the risk of MM in 4189 German subjects from the German Multiple Myeloma Group (GMMG) cohort (2121 MM cases and 2068 controls) and 1293 Spanish subjects (206 MM cases and 1087 controls). Results were then validated through meta-analysis with data from the UKBiobank (554 MM cases and 402,714 controls) and FinnGen cohorts (914 MM cases and 248,695 controls). Finally, we evaluated the correlation of these single nucleotide polymorphisms (SNPs) with cQTL data, serum inflammatory proteins, steroid hormones, and absolute numbers of blood-derived cell populations (n = 520). The meta-analysis of the four European cohorts showed no effect of obesity-related variants on the risk of developing MM. We only found a very modest association of the POC5rs2112347G and ADCY3rs11676272G alleles with MM risk that did not remain significant after correction for multiple testing (per-allele OR = 1.08, p = 0.0083 and per-allele OR = 1.06, p = 0.046). No correlation between these SNPs and functional data was found, which confirms that obesity-related variants do not influence MM risk.
dc.description.abstract
This work was supported by grants from the Instituto de Salud Carlos III (Madrid, Spain; PI17/02256 and PI20/01845), from the Consejería de Salud y Familia de la Junta de Andalucía (PY20/01282) and from the Dietmar Hopp Foundation and the German Ministry of Education and Science (BMBF: CLIOMMICS (01ZX1309)).
dc.format
application/pdf
dc.format
application/vnd.openxmlformats-officedocument.wordprocessingml.document
dc.format
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
dc.format
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
dc.relation
International Journal of Molecular Sciences;24(7)
dc.relation
https://doi.org/10.3390/ijms24076029
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Mieloma múltiple - Aspectes genètics
dc.subject
Obesitat - Complicacions
dc.subject
DISEASES::Hemic and Lymphatic Diseases::Hematologic Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Hemorrhagic Disorders::Hemostatic Disorders::Multiple Myeloma
dc.subject
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity
dc.subject
PHENOMENA AND PROCESSES::Genetic Phenomena::Genotype::Genetic Predisposition to Disease
dc.subject
ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades hematológicas::enfermedades hematológicas y linfáticas::enfermedades hematológicas::trastornos hemorrágicos::trastornos hemostáticos::mieloma múltiple
dc.subject
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::peso corporal::sobrepeso::obesidad
dc.subject
FENÓMENOS Y PROCESOS::fenómenos genéticos::genotipo::predisposición genética a la enfermedad
dc.title
GWAS-Identified Variants for Obesity Do Not Influence the Risk of Developing Multiple Myeloma: A Population-Based Study and Meta-Analysis
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
