SARS-CoV-2 Contacts’ Symptom Development and Secondary Attack Rate: A Retrospective Analysis of a Contact-Tracing Cohort in Catalonia

Other authors

[Mallafré-Larrosa M, Herrero Garcia M, Mendoza-Funes S, Martínez-Solanas È, Patsi-Bosch G, Mendioroz Peña J] Subdirecció General de Vigilància i Resposta a Emergències de Salut Pública, Departament de Salut, Generalitat de Catalunya, Barcelona, Spain. [Ciruela P] Subdirecció General de Vigilància i Resposta a Emergències de Salut Pública, Departament de Salut, Generalitat de Catalunya, Barcelona, Spain. CIBER Epidemiologia y Salud Pública (CIBERESP), Instituto Salud Carlos III, Madrid, Spain

Departament de Salut

Publication date

2023-04-13T11:46:07Z

2023-04-13T11:46:07Z

2023-03-24



Abstract

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Rastreig de contactes; Taxa d'atac secundari; Quarantena


Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Rastreo de contactos; Tasa de ataque secundario; Cuarentena


Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Contact tracing; Secondary attack rate; Quarantine


Contact tracing outcome indicators, such as symptom development (SD) and secondary attack rate (SAR) among close contacts (CCs), are key to understanding SARS-CoV-2 transmission. This study analyses SD and SAR and estimates the incubation period (IP) from a cohort of 47,729 CCs from 17,679 SARS-CoV-2 cases diagnosed in Catalonia (Spain) from May to August 2020. Globally, 19.4% of the CCs reported symptoms, especially adult women living in urban areas. SAR was 24.5%, notably higher among infants (37.6%), and 45.9% of secondary cases (SCs) were asymptomatic. Household CCs had 98% (OR: 1.98, 95% CI: 1.81–2.18) and 138% (2.38, 2.19–2.58) increased risk of SD and becoming SCs compared to social settings. The IP was 3.42 days, being 4.10 days among social CCs, and only 15.4% and 4.8% of SCs developed symptoms after days 7 and 10 of quarantine, respectively. These results, notably the higher SAR among asymptomatic children, highlight the importance of diligent monitoring to inform SARS-CoV-2 control strategies.

Document Type

Article


Published version

Language

English

Publisher

MDPI

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Rights

Attribution 4.0 International

http://creativecommons.org/licenses/by/4.0/

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