Sistema de Salut de Catalunya
Institut Català de la Salut
[Coll-Martinez C, Salavedra-Pont J, González-del-Rio M, Álvarez-Bravo, G] Girona Neuroimmumology and Multiple Sclerosis Unit, Neurology Department, Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain. Santa Caterina Hospital, Salt, Girona, Spain. Neurodegeneration and Neuroimflammation Research Group, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta, Salt, Spain. [Quintana E] Neurodegeneration and Neuroimflammation Research Group, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta, Salt, Spain. Medical Sciences Department, University of Girona, Girona, Spain. REEM, Multiple Sclerosis Spanish Network, Instituo de Salud Carlos III, Madrid, Spain. [Buxó M] Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta, Salt, Spain. [Gómez I, Muñoz-San Martín, M] Neurodegeneration and Neuroimflammation Research Group, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta, Salt, Spain. [Villar LM] REEM, Multiple Sclerosis Spanish Network, Instituto de Salud Carlos III, Madrid, Spain. Immunology Department, Ramon y Cajal University Hospital, IRYCIS, Madrid, Spain. [Robles-Cedeño R, Ramió-Torrentà Ll] Girona Neuroimmumology and Multiple Sclerosis Unit, Neurology Department, Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain. Neurodegeneration and Neuroimflammation Research Group, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta, Salt, Spain. Medical Sciences Department, University of Girona, Girona, Spain. REEM, Multiple Sclerosis Spanish Network, Instituo de Salud Carlos III, Madrid, Spain. [Gich J] Girona Neuroimmumology and Multiple Sclerosis Unit, Neurology Department, Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain. Neurodegeneration and Neuroimflammation Research Group, Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta, Salt, Spain. Medical Sciences Department, University of Girona, Girona, Spain
Hospital Universitari de Girona Dr Josep Trueta
2023-03-16T10:50:12Z
2023-03-16T10:50:12Z
2021-12
Bandes oligoclonals; Esclerosi múltiple; Disfunció cognitiva
Bandas oligoclonales; Esclerosis múltiple; Disfunción cognitiva
Oligoclonal bands; Multiple sclerosis; Cognitive dysfunction
Background: An association has been found between the presence of lipid-specific oligoclonal IgM bands (LS-OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course. Objective: To investigate lipid-specific oligoclonal IgM bands as a prognostic biomarker of cognitive impairment in the early stages of multiple sclerosis. Methods: Forty-four patients underwent neuropsychological assessment at baseline and 4 years. Cognitive performance at follow-up was compared adjusting by age, education, anxiety-depression, and baseline performance. Results: LS-OCMB+ patients only performed worse for Long-Term Storage in the Selective Reminding Test (p = .018). Conclusion: There are no remarkable cognitive differences between LS-OCMB- and LS-OCMB+ patients in the early stages of MS.
Article
Published version
English
Esclerosi múltiple; Marcadors bioquímics; Trastorns de la cognició; CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Oligoclonal Bands; DISEASES::Immune System Diseases::Autoimmune Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis; PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurocognitive Disorders::Cognition Disorders::Cognitive Dysfunction; COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::bandas oligoclonales; PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos neurocognitivos::trastornos cognitivos::disfunción cognitiva; ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple
Wiley
Brain and Behavior;11(12)
https://doi.org/10.1002/brb3.2405
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
