dc.contributor
Institut Català de la Salut
dc.contributor
[Gregori J] Grup de Recerca de les Malalties Hepàtiques, Unitat Hepàtica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Ibañez-Lligoña M, Quer J] Grup de Recerca de les Malalties Hepàtiques, Unitat Hepàtica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. Departament de Biologia Molecular i Bioquímica, Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Quer Sivila, Josep
dc.contributor.author
Gregori Font, Josep
dc.contributor.author
Ibañez Lligoña, Marta
dc.date.accessioned
2025-10-24T08:49:24Z
dc.date.available
2025-10-24T08:49:24Z
dc.date.issued
2023-03-01T11:44:19Z
dc.date.issued
2023-03-01T11:44:19Z
dc.date.issued
2023-01-09
dc.identifier
Gregori J, Ibañez-Lligoña M, Quer J. Quantifying In-Host Quasispecies Evolution. Int J Mol Sci. 2023 Jan 9;24(2):1301.
dc.identifier
https://hdl.handle.net/11351/9083
dc.identifier
10.3390/ijms24021301
dc.identifier
000917755000001
dc.identifier.uri
http://hdl.handle.net/11351/9083
dc.description.abstract
Mutagenesis; Quasispecies evolution; Viral treatment
dc.description.abstract
Mutagénesis; Evolución de las cuasiespecies; Tratamiento viral
dc.description.abstract
Mutagènesi; Evolució de les quasiespècies; Tractament viral
dc.description.abstract
What takes decades, centuries or millennia to happen with a natural ecosystem, it takes only days, weeks or months with a replicating viral quasispecies in a host, especially when under treatment. Some methods to quantify the evolution of a quasispecies are introduced and discussed, along with simple simulated examples to help in the interpretation and understanding of the results. The proposed methods treat the molecules in a quasispecies as individuals of competing species in an ecosystem, where the haplotypes are the competing species, and the ecosystem is the quasispecies in a host, and the evolution of the system is quantified by monitoring changes in haplotype frequencies. The correlation between the proposed indices is also discussed, and the R code used to generate the simulations, the data and the plots is provided. The virtues of the proposed indices are finally shown on a clinical case.
dc.description.abstract
This study was partially supported by Pla Estratègic de Recerca i Innovació en Salut (PERIS)—Direcció General de Recerca i Innovació en Salut (DGRIS), Catalan Health Ministry, Generalitat de Catalunya; the Spanish Network for the Research in Infectious Diseases (REIPI RD16/0016/0003) from the European Regional Development Fund (ERDF); Centro para el Desarrollo Tecnológico Industrial (CDTI) from the Spanish Ministry of Economy and Business, grant number IDI-20200297; grant PI19/00301 and PI22/00258 from Instituto de Salud Carlos III cofinanced by the European Regional Development Fund (ERDF), and Gilead’s biomedical research project GLD21/00006.
dc.format
application/pdf
dc.relation
International Journal of Molecular Sciences;24(2)
dc.relation
https://doi.org/10.3390/ijms24021301
dc.relation
info:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0016%2F0003
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Virus - Reproducció
dc.subject
Evolució molecular
dc.subject
PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::Quasispecies
dc.subject
PHENOMENA AND PROCESSES::Genetic Phenomena::Biological Evolution::Evolution, Molecular
dc.subject
FENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::cuasiespecies
dc.subject
FENÓMENOS Y PROCESOS::fenómenos genéticos::evolución biológica::evolución molecular
dc.title
Quantifying In-Host Quasispecies Evolution
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
