dc.contributor
Institut Català de la Salut
dc.contributor
[Graves JS] Department of Neurosciences, University of California San Diego, San Diego, California, USA. [Ganzetti M, Dondelinger F, Lipsmeier F, Belachew S, Bernasconi C] F. Hoffmann-La Roche Ltd, Basel, Switzerland. [Montalban X] Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Graves, Jennifer
dc.contributor.author
Ganzetti, Marco
dc.contributor.author
Dondelinger, Frank
dc.contributor.author
Lipsmeier, Florian
dc.contributor.author
Belachew, Shibeshih Mitiku
dc.contributor.author
Montalban Gairín, Xavier
dc.contributor.author
Bernasconi, Corrado
dc.date.accessioned
2025-10-24T10:39:50Z
dc.date.available
2025-10-24T10:39:50Z
dc.date.issued
2023-02-21T11:01:18Z
dc.date.issued
2023-02-21T11:01:18Z
dc.identifier
Graves JS, Ganzetti M, Dondelinger F, Lipsmeier F, Belachew S, Bernasconi C, et al. Preliminary validity of the Draw a Shape Test for upper extremity assessment in multiple sclerosis. Ann Clin Transl Neurol. 2023 Feb;10(2):166–80.
dc.identifier
https://hdl.handle.net/11351/9023
dc.identifier
10.1002/acn3.51705
dc.identifier
000903379800001
dc.identifier.uri
http://hdl.handle.net/11351/9023
dc.description.abstract
Multiple sclerosis
dc.description.abstract
Esclerosi múltiple
dc.description.abstract
Esclerosis múltiple
dc.description.abstract
Objective
To validate the smartphone sensor-based Draw a Shape Test – a part of the Floodlight Proof-of-Concept app for remotely assessing multiple sclerosis-related upper extremity impairment by tracing six different shapes.
Methods
People with multiple sclerosis, classified functionally normal/abnormal via their Nine-Hole Peg Test time, and healthy controls participated in a 24-week, nonrandomized study. Spatial (trace accuracy), temporal (mean and variability in linear, angular, and radial drawing velocities, and dwell time ratio), and spatiotemporal features (trace celerity) were cross-sectionally analyzed for correlation with standard clinical and brain magnetic resonance imaging (normalized brain volume and total lesion volume) disease burden measures, and for capacity to differentiate people with multiple sclerosis from healthy controls.
Results
Data from 69 people with multiple sclerosis and 18 healthy controls were analyzed. Trace accuracy (all shapes), linear velocity variability (circle, figure-of-8, spiral shapes), and radial velocity variability (spiral shape) had a mostly fair/moderate-to-good correlation (|r| = 0.14–0.66) with all disease burden measures. Trace celerity also had mostly fair/moderate-to-good correlation (|r| = 0.18–0.41) with Nine-Hole Peg Test performance, cerebellar functional system score, and brain magnetic resonance imaging. Furthermore, partial correlation analysis related these results to motor impairment. People with multiple sclerosis showed greater drawing velocity variability, though slower mean velocity, than healthy controls. Linear velocity (spiral shape) and angular velocity (circle shape) potentially differentiate functionally normal people with multiple sclerosis from healthy controls.
Interpretation
The Draw a Shape Test objectively assesses upper extremity impairment and correlates with all disease burden measures, thus aiding multiple sclerosis-related upper extremity impairment characterization.
dc.description.abstract
This research was funded by F. Hoffmann-La Roche Ltd, Basel, Switzerland.
dc.format
application/pdf
dc.relation
Annals of Clinical and Translational Neurology;10(2)
dc.relation
https://doi.org/10.1002/acn3.51705
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Esclerosi múltiple - Imatgeria per ressonància magnètica
dc.subject
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
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Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
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ANATOMY::Body Regions::Extremities::Upper Extremity
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ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
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ANATOMÍA::regiones corporales::extremidades::extremidad superior
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética
dc.title
Preliminary validity of the Draw a Shape Test for upper extremity assessment in multiple sclerosis
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
