dc.contributor
Institut Català de la Salut
dc.contributor
[Adukauskiene D, Ciginskiene A] Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. [Adukauskaite A] Department of Cardiology and Angiology, University Hospital of Innsbruck, Innsbruck, Austria. [Koulenti D] Second Critical Care Department, Attikon University Hospital, Athens, Greece. UQ Centre for Clinical Research (UQCCR), Faculty of Medicine, The Univesrity of Queensland, Brisbane, Australia. [Rello J] Vall d‘Hebron Institut de Recerca (VHIR), Barcelona, Spain. Clinical Research, CHU Nîmes, Nîmes, France
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Adukauskienė, Dalia
dc.contributor.author
Čiginskienė, Aušra
dc.contributor.author
Adukauskaite, Agne
dc.contributor.author
Koulenti, Despoina
dc.contributor.author
Rello, Jordi
dc.date.accessioned
2025-10-24T08:52:29Z
dc.date.available
2025-10-24T08:52:29Z
dc.date.issued
2022-10-11T08:38:13Z
dc.date.issued
2022-10-11T08:38:13Z
dc.date.issued
2022-07-04
dc.identifier
Adukauskiene D, Ciginskiene A, Adukauskaite A, Koulenti D, Rello J. Clinical Features and Outcomes of Monobacterial and Polybacterial Episodes of Ventilator-Associated Pneumonia Due to Multidrug-Resistant Acinetobacter baumannii. Antibiotics. 2022 Jul 4;11(7):892.
dc.identifier
https://hdl.handle.net/11351/8284
dc.identifier
10.3390/antibiotics11070892
dc.identifier
000833708300001
dc.identifier.uri
http://hdl.handle.net/11351/8284
dc.description.abstract
Aspiration pneumonia; Multidrug-resistance; Polymicrobial
dc.description.abstract
Neumonía por aspiración; Resistencia a múltiples fármacos; Polimicrobiano
dc.description.abstract
Pneumònia per aspiració; Resistència a múltiples fàrmacs; Polimicrobiana
dc.description.abstract
Multidrug-resistant A. baumannii (MDRAB) VAP has high morbidity and mortality, and the rates are constantly increasing globally. Mono- and polybacterial MDRAB VAP might differ, including outcomes. We conducted a single-center, retrospective (January 2014–December 2016) study in the four ICUs (12–18–24 beds each) of a reference Lithuanian university hospital, aiming to compare the clinical features and the 30-day mortality of monobacterial and polybacterial MDRAB VAP episodes. A total of 156 MDRAB VAP episodes were analyzed: 105 (67.5%) were monomicrobial. The 30-day mortality was higher (p < 0.05) in monobacterial episodes: overall (57.1 vs. 37.3%), subgroup with appropriate antibiotic therapy (50.7 vs. 23.5%), and subgroup of XDR A. baumannii (57.3 vs. 36.4%). Monobacterial MDRAB VAP was associated (p < 0.05) with Charlson comorbidity index ≥3 (67.6 vs. 47.1%), respiratory comorbidities (19.0 vs. 5.9%), obesity (27.6 vs. 9.8%), prior hospitalization (58.1 vs. 31.4%), prior antibiotic therapy (99.0 vs. 92.2%), sepsis (88.6 vs. 76.5%), septic shock (51.9 vs. 34.6%), severe hypoxemia (23.8 vs. 7.8%), higher leukocyte count on VAP onset (median [IQR] 11.6 [8.4–16.6] vs. 10.9 [7.3–13.4]), and RRT need during ICU stay (37.1 vs. 17.6%). Patients with polybacterial VAP had a higher frequency of decreased level of consciousness (p < 0.05) on ICU admission (29.4 vs. 14.3%) and on VAP onset (29.4 vs. 11.4%). We concluded that monobacterial MDRAB VAP had different demographic/clinical characteristics compared to polybacterial and carried worse outcomes. These important findings need to be validated in a larger, prospective study, and the management implications to be further investigated.
dc.format
application/pdf
dc.relation
Antibiotics;11(7)
dc.relation
https://doi.org/10.3390/antibiotics11070892
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Microorganismes - Resistència als medicaments
dc.subject
Pneumònia - Tractament
dc.subject
DISEASES::Bacterial Infections and Mycoses::Infection::Cross Infection::Pneumonia, Ventilator-Associated
dc.subject
PHENOMENA AND PROCESSES::Microbiological Phenomena::Bacterial Physiological Phenomena::Drug Resistance, Bacterial::Drug Resistance, Multiple, Bacterial
dc.subject
ORGANISMS::Bacteria::Gram-Negative Bacteria::Gram-Negative Aerobic Bacteria::Gram-Negative Aerobic Rods and Cocci::Moraxellaceae::Acinetobacter::Acinetobacter baumannii
dc.subject
ENFERMEDADES::infecciones bacterianas y micosis::infección::infección hospitalaria::neumonía asociada al ventilador
dc.subject
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::fenómenos fisiológicos bacterianos::farmacorresistencia bacteriana::farmacorresistencia bacteriana múltiple
dc.subject
ORGANISMOS::Bacteria::bacterias gramnegativas::bacterias aerobias gramnegativas::bacilos y cocos aerobios gramnegativos::Moraxellaceae::Acinetobacter::Acinetobacter baumannii
dc.title
Clinical Features and Outcomes of Monobacterial and Polybacterial Episodes of Ventilator-Associated Pneumonia Due to Multidrug-Resistant Acinetobacter baumannii
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
