Sistema de Salut de Catalunya
[Sans-De San Nicolàs L, De Jesús-Gil C, García-Jiménez I] Grup d’Immunologia Translacional, Departament de Biologia Cel·lular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB), Parc Científic de Barcelona (PCB), Barcelona, Spain. [Figueras-Nart I, Bonfill-Ortí M] Departament de Dermatologia, Hospital de Bellvitge, Universitat de Barcelona (UB), L’Hospitalet de Llobregat, Spain. [Guilabert A] Departament de Dermatologia, Hospital General de Granollers, Granollers, Spain
Hospital General de Granollers
2022-09-13T07:23:21Z
2022-09-13T07:23:21Z
2022-06-30
Atopic dermatitis; Cutaneous lymphocyte antigen; Skin infections
Dermatitis atópica; Antígeno cutáneo de linfocitos; Infecciones de la piel
Dermatitis atòpica; Antigen limfòcit cutani; Infeccions de la pell
Staphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant play-ers in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo coculture model made of purified circu-lating CLA+/− effector and central memory T cells and autologous lesional epidermal cells was established. We show a CLA-dependent production of IL-13 upon activation with staphylococcal enterotoxin B (SEB) that allows the differentiation of the Th2 high and Th2 low groups, with distinct clinical correlations between both groups, within a clinically homogeneous population of adult non-treated moderate-to- severe AD patients.
Article
Accepted version
English
Dermatitis atòpica; Estafilococs daurats; Pell - Infeccions; DISEASES::Skin and Connective Tissue Diseases::Skin Diseases::Dermatitis::Skin and Connective Tissue Diseases::Skin Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Dermatitis, Atopic; ORGANISMS::Bacteria::Bacteria::Firmicutes::Bacillales::Staphylococcaceae::Staphylococcus::Bacteria::Bacteria::Staphylococcus aureus; ANATOMY::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes; ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::dermatitis::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::dermatitis atópica; ORGANISMOS::Bacteria::Bacteria::Firmicutes::Bacillales::Staphylococcaceae::Staphylococcus::Bacteria::Bacteria::Staphylococcus aureus; ANATOMÍA::células::células sanguíneas::leucocitos::leucocitos mononucleares::linfocitos::linfocitos T
Wiley
Allergy;
https://doi.org/10.1111/all.15424
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
Articles científics - HG [171]
