dc.contributor
Institut Català de la Salut
dc.contributor
[Chondronasiou D, Berenguer-Llergo A, Aguilera M] Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. [Gill D] Epigenetics Programme, Babraham Institute, Cambridge, UK. [Mosteiro L] Genentech, San Francisco, USA. [Urdinguio RG] Cancer Epigenetics and Nanomedicine Laboratory, Nanomaterials and Nanotechnology Research Center (CINN CSIC), Oviedo, Spain. Health Research Institute of Asturias (ISPA), Oviedo, Spain. Institute of Oncology of Asturias (IUOPA), University of Oviedo, Oviedo, Spain. Department of Organisms and Systems Biology (BOS), University of Oviedo, Oviedo, Spain. CIBER of Rare Diseases (CIBERER), Oviedo, Spain. [Abad M] Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Chondronasiou, Dafni
dc.contributor.author
Gill, Diljeet
dc.contributor.author
Mosteiro, Lluc
dc.contributor.author
Urdinguio, Rocio G
dc.contributor.author
Berenguer-LLergo, Antoni
dc.contributor.author
Aguilera Pujabet, Mònica
dc.contributor.author
Abad Mendez, Maria
dc.date.accessioned
2025-10-25T05:38:39Z
dc.date.available
2025-10-25T05:38:39Z
dc.date.issued
2022-07-21T10:00:06Z
dc.date.issued
2022-07-21T10:00:06Z
dc.identifier
Chondronasiou D, Gill D, Mosteiro L, Urdinguio RG, Berenguer-Llergo A, Aguilera M, et al. Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. Aging Cell. 2022 Mar;21(3):e13578.
dc.identifier
https://hdl.handle.net/11351/7895
dc.identifier
10.1111/acel.13578
dc.identifier
000763005500001
dc.identifier.uri
http://hdl.handle.net/11351/7895
dc.description.abstract
Aging; Epigenetic clocks; Pluripotency
dc.description.abstract
Envelliment; Rellotges epigenètics; Pluripotència
dc.description.abstract
Envejecimiento; Relojes epigenéticos; Pluripotencia
dc.description.abstract
The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can convert somatic differentiated cells into pluripotent stem cells in a process known as reprogramming. Notably, partial and reversible reprogramming does not change cell identity but can reverse markers of aging in cells, improve the capacity of aged mice to repair tissue injuries, and extend longevity in progeroid mice. However, little is known about the mechanisms involved. Here, we have studied changes in the DNA methylome, transcriptome, and metabolome in naturally aged mice subject to a single period of transient OSKM expression. We found that this is sufficient to reverse DNA methylation changes that occur upon aging in the pancreas, liver, spleen, and blood. Similarly, we observed reversion of transcriptional changes, especially regarding biological processes known to change during aging. Finally, some serum metabolites and biomarkers altered with aging were also restored to young levels upon transient reprogramming. These observations indicate that a single period of OSKM expression can drive epigenetic, transcriptomic, and metabolomic changes toward a younger configuration in multiple tissues and in the serum.
dc.format
application/pdf
dc.relation
Aging Cell;21(3)
dc.relation
https://doi.org/10.1111/acel.13578
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Cèl·lules mare
dc.subject
Cèl·lules - Envelliment
dc.subject
PHENOMENA AND PROCESSES::Genetic Phenomena
dc.subject
FENÓMENOS Y PROCESOS::fenómenos genéticos
dc.title
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
