dc.contributor
Institut Català de la Salut
dc.contributor
[Ronsmans S] Centre for Environment and Health, KU Leuven, Leuven, Belgium. [Sørig Hougaard K] National Research Centre for the Working Environment, Copenhagen, Denmark. [Nawrot TS] Centre for Environment and Health, KU Leuven, Leuven, Belgium. Centre for Environmental Sciences, University of Hasselt, Hasselt, Belgium. [Plusquin M] Centre for Environmental Sciences, University of Hasselt, Hasselt, Belgium. [Huaux F] Louvain Centre for Toxicology and Applied Pharmacology, Université Catholique de Louvain, Brussels, Belgium. [Jesús Cruz M] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Ronsmans, Steven
dc.contributor.author
Hougaard, Karin Sørig
dc.contributor.author
Nawrota, Tim S.
dc.contributor.author
Plusquin, Michelle
dc.contributor.author
Huaux, François
dc.contributor.author
Cruz Carmona, Mª Jesús
dc.date.accessioned
2025-10-24T08:55:47Z
dc.date.available
2025-10-24T08:55:47Z
dc.date.issued
2022-07-20T10:15:57Z
dc.date.issued
2022-07-20T10:15:57Z
dc.identifier
Ronsmans S, Sørig Hougaard K, Nawrot TS, Plusquin M, Huaux F, Jesús Cruz M, et al. The EXIMIOUS project—Mapping exposure-induced immune effects: connecting the exposome and the immunome. Environ Epidemiol. 2022 Feb;6(1):e193.
dc.identifier
https://hdl.handle.net/11351/7872
dc.identifier
10.1097/EE9.0000000000000193
dc.identifier
000784746300011
dc.identifier.uri
http://hdl.handle.net/11351/7872
dc.description.abstract
External exposome; Immune-mediated diseases; Immunome
dc.description.abstract
Exposoma extern; Malalties immunomediades; Immunoma
dc.description.abstract
Exposoma externo; Enfermedades inmunomediadas; Inmunoma
dc.description.abstract
Immune-mediated, noncommunicable diseases—such as autoimmune and inflammatory diseases—are chronic disorders, in which the interaction between environmental exposures and the immune system plays an important role. The prevalence and societal costs of these diseases are rising in the European Union. The EXIMIOUS consortium—gathering experts in immunology, toxicology, occupational health, clinical medicine, exposure science, epidemiology, bioinformatics, and sensor development—will study eleven European study populations, covering the entire lifespan, including prenatal life. Innovative ways of characterizing and quantifying the exposome will be combined with high-dimensional immunophenotyping and -profiling platforms to map the immune effects (immunome) induced by the exposome. We will use two main approaches that “meet in the middle”—one starting from the exposome, the other starting from health effects. Novel bioinformatics tools, based on systems immunology and machine learning, will be used to integrate and analyze these large datasets to identify immune fingerprints that reflect a person’s lifetime exposome or that are early predictors of disease. This will allow researchers, policymakers, and clinicians to grasp the impact of the exposome on the immune system at the level of individuals and populations.
dc.description.abstract
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874707.
dc.format
application/pdf
dc.publisher
Wolters Kluwer Health
dc.relation
Environmental Epidemiology;6(1)
dc.relation
http://dx.doi.org/10.1097/EE9.0000000000000193
dc.relation
info:eu-repo/grantAgreement/EC/H2020/874707
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Malalties autoimmunitàries
dc.subject
DISEASES::Immune System Diseases::Autoimmune Diseases
dc.subject
ENFERMEDADES::enfermedades del sistema inmune::enfermedades autoinmunes
dc.title
The EXIMIOUS project—Mapping exposure-induced immune effects: connecting the exposome and the immunome
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
