Sistema de Salut de Catalunya
Institut Català de la Salut
[Boada M] Research Center and Memory Clinic, Fundació ACEInstitut Català de Neurociències Aplicades - Universitat Internacional de Catalunya, Barcelona, Spain. Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Barcelona, Spain. [Rodrigo A] GMV SECURE E SOLUTIONS, Valencia, Spain. [Jessen F] Department of Psychiatry, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, Cologne, Germany. [Wimblad B] Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden. Theme Aging, Karolinska Univ Hospital, Stockholm, Sweden. [Kramberger M] Center for Cognitive Impairments, Department of Neurology, University Medical Center Ljubljana, Ljubljana, Slovenia. [Visser PJ] Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit AmsterdamAmsterdam UMC, Amsterdam, the Netherlands. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands. [Simó R, Ciudin A] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER de Diabetes y Enfermedades Metabólicas Asociadas. Instituto de Salud Carlos III, Spain
Vall d'Hebron Barcelona Hospital Campus
2022-06-27T11:55:05Z
2022-06-27T11:55:05Z
2022-06
Diagnostic gap; Early diagnosis; Population
Brecha de diagnóstico; Diagnóstico precoz; Población
Bretxa de diagnòstic; Diagnòstic precoç; Població
Introduction: The Models of Patient Engagement for Alzheimer's Disease (MOPEAD) project was conceived to explore innovative complementary strategies to uncover hidden prodromal and mild Alzheimer's disease (AD) dementia cases and to raise awareness both in the general public and among health professionals about the importance of early diagnosis. Methods: Four different strategies or RUNs were used: (a) a web-based (WB) prescreening tool, (2) an open house initiative (OHI), (3) a primary care-based protocol for early detection of cognitive decline (PC), and (4) a tertiary care-based pre-screening at diabetologist clinics (DC). Results: A total of 1129 patients at high risk of having prodromal AD or dementia were identified of 2847 pre-screened individuals (39.7%). The corresponding proportion for the different initiatives were 36.8% (WB), 35.6% (OHI), 44.4% (PC), and 58.3% (DC). Conclusion: These four complementary pre-screening strategies were useful for identifying individuals at high risk of having prodromal or mild AD.
This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under Grant Agreement No 115985. This Joint Undertaking receives support from the European Union's Horizon 2020 Research and Innovation program and the European Federation of Pharmaceutical Industries and Associations. www.imi.europa.eu/. All participants provided informed consent.
Article
Published version
English
Alzheimer, Malaltia d' - Diagnòstic; Pacients - Participació; Cribatge (Medicina); DISEASES::Nervous System Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies::Alzheimer Disease; Other subheadings::Other subheadings::/diagnosis; PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Attitude::Attitude to Health::Treatment Adherence and Compliance::Patient Acceptance of Health Care::Patient Participation; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Mass Screening; ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso::enfermedades neurodegenerativas::taupatías::enfermedad de Alzheimer; Otros calificadores::Otros calificadores::/diagnóstico; PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::actitud::actitud ante la salud::cumplimiento y adherencia al tratamiento::aceptación de la asistencia sanitaria por parte del paciente::participación del paciente; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::cribado sistemático
Wiley
Alzheimer's & Dementia;18(6)
https://doi.org/10.1002/alz.12441
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
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