Sistema de Salut de Catalunya
Institut Català de la Salut
[Zanga G] Department of Neurology, César Milstein Hospital, associated with University of Buenos Aires, Buenos Aires, Argentina. [Drzewiscki E, Esnaola Rojas MM] Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Tagliani P] Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Smietniansky M] Department of Internal Medicine Interna, Programa de Medicine Geriatric Program, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. [Caruso D] Department of Internal Medicine, César Milstein Hospital, associated with University of Buenos Aires, Buenos Aires, Argentina
Vall d'Hebron Barcelona Hospital Campus
2022-06-20T08:08:43Z
2022-06-20T08:08:43Z
2021-10-05
Disease-modifying therapies; Multiple sclerosis; Predictors
Terapias modificadoras de la enfermedad; Esclerosis múltiple; Predictores
Teràpies modificadores de la malaltia; Esclerosi múltiple; Predictors
Background and Aims: In multiple sclerosis (MS), non-adherence/non-persistence is related to suboptimal response to treatment, including disease relapses and the need for more expensive healthcare. The aim of this study was to identify predictors related to adherence to disease modifying therapies (DMTs) in a cohort of Argentinian MS patients. Methods: We conducted a cross-sectional study at the National Medical Care Program from Argentina. MS patients with at least one claim for a DMT from 1 January 2017 to 1 October 2017 were identified. A telephone survey was performed to assess clinical and demographic factors. The medication possession ratio (MPR) was used to estimate adherence; MPR <80% defined non-adherence. Associations were studied using a logistic regression model. Results: Our database included 648 MS patients. A total of 360 patients (60% females, mean age 55.3 years) accepted to participate. Of these, 308 (85.5%) patients were receiving DMT at the time of the survey. Some 198 (63.7%) were receiving injectable therapies. Optimal adherence was 47.7%. Adherence was associated with oral medication [odds ratio (OR) 1.83 95% confidence interval (CI) 1.13–3.00, p = 0.014]. A factor related to oral drugs was higher educational level (OR 2.86 95%CI 1.41–5.81, p = 0.004). Conclusion: This real-world study showed better adherence and persistence on treatment with oral therapies in MS patients in Argentina.
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: GZ disclosed receipt of the following financial support for the research, authorship and/or publication of this article: this study was supported by a research grant awarded by the Florencio Fiorini Foundation. The article processing charges was funded by Roche.
Article
Published version
English
Esclerosi múltiple - Tractament; Medicació oral; Pacients - Cooperació; DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis; Other subheadings::Other subheadings::Other subheadings::/drug therapy; PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Attitude::Attitude to Health::Treatment Adherence and Compliance::Patient Acceptance of Health Care::Patient Compliance::Medication Adherence; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Drug Therapy::Drug Administration Routes::Administration, Oral; ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple; Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia; PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::actitud::actitud ante la salud::cumplimiento y adherencia al tratamiento::aceptación de la asistencia sanitaria por parte del paciente::cumplimiento del paciente::adhesión a la medicación; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::farmacoterapia::vías de administración de medicamentos::administración oral
SAGE Publications
Therapeutic Advances in Neurological Disorders;14
https://doi.org/10.1177/17562864211031099
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
Articles científics - CEMCAT [136]
Articles científics - HVH [3396]
