dc.contributor
Institut Català de la Salut
dc.contributor
Grup de Recerca en Malalties Neurodegeneratives, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Lorente-Picón, Marina
dc.contributor.author
Laguna Tuset, Ariadna
dc.date.accessioned
2025-10-25T08:54:59Z
dc.date.available
2025-10-25T08:54:59Z
dc.date.issued
2022-03-30T09:14:52Z
dc.date.issued
2022-03-30T09:14:52Z
dc.identifier
Lorente-Picón M, Laguna A. New Avenues for Parkinson’s Disease Therapeutics: Disease-Modifying Strategies Based on the Gut Microbiota. Biomolecules. 2021 Mar;11(3):433.
dc.identifier
https://hdl.handle.net/11351/7275
dc.identifier
10.3390/biom11030433
dc.identifier
000633435800001
dc.identifier.uri
http://hdl.handle.net/11351/7275
dc.description.abstract
Dieta mediterrània; Microbiota intestinal; Prebiòtics
dc.description.abstract
Dieta mediterránea; Microbiota intestinal; Prebióticos
dc.description.abstract
Mediterranean diet; Gut microbiota; Prebiotics
dc.description.abstract
Parkinson’s disease (PD) is a multifactorial neurodegenerative disorder that currently affects 1% of the population over the age of 60 years, and for which no disease-modifying treatments exist. Neurodegeneration and neuropathology in different brain areas are manifested as both motor and non-motor symptoms in patients. Recent interest in the gut–brain axis has led to increasing research into the gut microbiota changes in PD patients and their impact on disease pathophysiology. As evidence is piling up on the effects of gut microbiota in disease development and progression, another front of action has opened up in relation to the potential usage of microbiota-based therapeutic strategies in treating gastrointestinal alterations and possibly also motor symptoms in PD. This review provides status on the different strategies that are in the front line (i.e., antibiotics; probiotics; prebiotics; synbiotics; dietary interventions; fecal microbiota transplantation, live biotherapeutic products), and discusses the opportunities and challenges the field of microbiome research in PD is facing.
dc.description.abstract
This work was supported by funds from the La Caixa Banking Foundation (Junior LeaderFellowship LCF/BQ/PR19/11700005) to A.L.
dc.format
application/pdf
dc.relation
Biomolecules;11(3)
dc.relation
https://doi.org/10.3390/biom11030433
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Parkinson, Malaltia de - Microbiologia
dc.subject
Intestins - Microbiologia
dc.subject
Suplements nutritius - Ús terapèutic
dc.subject
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders::Parkinson Disease
dc.subject
Other subheadings::Other subheadings::Other subheadings::/microbiology
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Fecal Microbiota Transplantation
dc.subject
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Neuroprotective Agents
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/microbiología
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::trasplante fecal
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::sustancias protectoras::fármacos neuroprotectores
dc.title
New Avenues for Parkinson’s Disease Therapeutics: Disease-Modifying Strategies Based on the Gut Microbiota
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
