Sistema de Salut de Catalunya
Institut Català de la Salut
[Martínez-Horta S, Bejr-Kasem H, Horta-Barba A, Pascual-Sedano B] Movement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain. Centro de Investigación en Red-Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. [Santos-García D] CHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain. [de Deus Fonticoba T] Complejo Hospitalario Universitario de Ferrol (CHUF), Ferrol, A Coruña, Spain. [Hernández Vara J, de Fábregues O ] Servei de Neurologia, Grup de Recerca en Malalties Neurodegeneratives, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Solano-Vila B] Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain. Hospital Santa Caterina, Institut d’Assistència Sanitària (IAS), Salt, Spain
Hospital Universitari de Girona Dr Josep Trueta
2022-03-07T11:42:57Z
2022-03-07T11:42:57Z
2021-12-08
Malaltia de Parkinson; Cognició; Estil de vida
Enfermedad de Parkinson; Cognición; Estilo de vida
Parkinson Disease; Cognition; Life Style
Background: Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson's disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results: Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p < 0.05) and cognitive stimulation (< 0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p < 0.05), Il6 (p < 0.05), iron (p < 0.05), and homocysteine (p < 0.005) levels, and positively associated with vitamin B12 levels (p < 0.005). Conclusions: We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD.
Fundación Curemos el Parkinson (https:// curem oselp arkin son. org/) covered the expenses derived from hiring a CRO and from carrying out complementary tests.
Article
Published version
English
Parkinson, Malaltia de; Cognició; PSYCHIATRY AND PSYCHOLOGY::Psychological Phenomena::Mental Processes::Cognition; PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Psychology, Social::Life Style; DISEASES::Nervous System Diseases::Nervous System Diseases::Nervous System Diseases::Neurodegenerative Diseases::Parkinson Disease; ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso::enfermedades del sistema nervioso::enfermedades neurodegenerativas::enfermedad de Parkinson; PSIQUIATRÍA Y PSICOLOGÍA::fenómenos psicológicos::procesos mentales::cognición; PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::psicología social::estilo de vida
BioMed Central
BMC Neurology;21(1)
https://doi.org/10.1186/s12883-021-02485-1
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
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