dc.contributor
Institut Català de la Salut
dc.contributor
[González-Martínez S] Clinical Researcher, Hospital Ramón y Cajal, 28034 Madrid, Spain. [Pérez-Mies B, Palacios J] Department of Pathology, Hospital Ramón y Cajal, 28034 Madrid, Spain. Institute Ramón y Cajal for Health Research (IRYCIS), 28034 Madrid, Spain. CIBER-ONC, Instituto de Salud Carlos III, 28029 Madrid, Spain. Faculty of Medicine, University of Alcalá de Henares, Alcalá de Henares, 28801 Madrid, Spain. [Pizarro D, Caniego-Casas T] Institute Ramón y Cajal for Health Research (IRYCIS), 28034 Madrid, Spain. [Cortés J] CIBER-ONC, Instituto de Salud Carlos III, 28029 Madrid, Spain. Faculty of Biomedical and Health Sciences, Department of Medicine, Universidad Europea de Madrid, 28670 Madrid, Spain. International Breast Cancer Center (IBCC), Quironsalud Group, 08017 Barcelona, Spain. Medica Scientia Innovation Research, 08007 Barcelona, Spain. Medica Scientia Innovation Research, Ridgewood, NJ 07450, USA. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
González-Martínez, Silvia
dc.contributor.author
Pérez-Mies, Belén
dc.contributor.author
Pizarro, David
dc.contributor.author
Caniego-Casas, Tamara
dc.contributor.author
Cortés Castan, Javier
dc.contributor.author
Palacios, José
dc.date.accessioned
2025-10-25T05:39:36Z
dc.date.available
2025-10-25T05:39:36Z
dc.date.issued
2022-01-31T11:03:01Z
dc.date.issued
2022-01-31T11:03:01Z
dc.identifier
González-Martínez S, Pérez-Mies B, Pizarro D, Caniego-Casas T, Cortés J, Palacios J. Epithelial Mesenchymal Transition and Immune Response in Metaplastic Breast Carcinoma. Int J Mol Sci. 2021 Jul;22(14):7398.
dc.identifier
https://hdl.handle.net/11351/6937
dc.identifier
10.3390/ijms22147398
dc.identifier
000676513000001
dc.identifier.uri
http://hdl.handle.net/11351/6937
dc.description.abstract
Transició epitelial-mesenquimal; Carcinoma de mama metaplàstic
dc.description.abstract
Transición epitelio-mesenquimatosa; Carcinoma de mama metaplasico
dc.description.abstract
Epithelial-mesenchymal transition; Metaplastic breast carcinoma
dc.description.abstract
Metaplastic breast carcinoma (MBC) is a heterogeneous group of infrequent triple negative (TN) invasive carcinomas with poor prognosis. MBCs have a different clinical behavior from other types of triple negative breast cancer (TNBC), being more resistant to standard chemotherapy. MBCs are an example of tumors with activation of epithelial–mesenchymal transition (EMT). The mechanisms involved in EMT could be responsible for the increase in the infiltrative and metastatic capacity of MBCs and resistance to treatments. In addition, a relationship between EMT and the immune response has been seen in these tumors. In this sense, MBC differ from other TN tumors showing a lower number of tumor-infiltrating lymphocytes (TILS) and a higher percentage of tumor cells expressing programmed death-ligand 1 (PD-L1). A better understanding of the relationship between the immune system and EMT could provide new therapeutic approaches in MBC.
dc.description.abstract
This review was funded by grants from the Instituto de Salud Carlos III (ISCIII) (PI19/01331) and CIBERONC (CB16/12/00316 and CB16/12/00449), co-financed by the European Development Regional Fund. ‘A way to achieve Europe’ (FEDER), and by the Spanish Association Against Cancer Scientific Foundation (Grupos Coordinados Traslacionales aecc 2018).
dc.format
application/pdf
dc.relation
International Journal of Molecular Sciences;22(14)
dc.relation
https://doi.org/10.3390/ijms22147398
dc.relation
info:eu-repo/grantAgreement/ES/PE2013-2016/CB16%2F12%2F00449
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Mama - Càncer - Tractament
dc.subject
Cèl·lules - Transformació
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Fisiologia cel·lular
dc.subject
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Transdifferentiation::Epithelial-Mesenchymal Transition
dc.subject
Other subheadings::Other subheadings::/drug effects
dc.subject
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
dc.subject
Other subheadings::Other subheadings::Other subheadings::/immunology
dc.subject
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::transdiferenciación celular::transición epiteliomesenquimatosa
dc.subject
Otros calificadores::Otros calificadores::/efectos de los fármacos
dc.subject
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/inmunología
dc.title
Epithelial Mesenchymal Transition and Immune Response in Metaplastic Breast Carcinoma
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
