dc.contributor
Institut Català de la Salut
dc.contributor
[Siegler JE] Cooper Neurologic Institute, Cooper University Hospital, Camden, NJ, USA. Cooper Medical School of Rowan University, Camden NJ, USA. [Cardona P, Talavera B, Guillen AN, Chavarría-Miranda A] Department of Neurology, Hospital Universitari, Bellvitge, Barcelona, Spain. [Arenillas JF] Department of Neurology, Hospital Clínico Universitario, Valladolid, Spain. Neurovascular Research Laboratory, Instituto de Biología y Genética Molecular, Universidad de Valladolid, Consejo Superior de Investigaciones Científicas, Madrid, Spain. [Requena M, Ribo M] Department of Neurosurgery, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA. Unitat d’Ictus, Servei de Neurologia, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Cardona, Pere
dc.contributor.author
Talavera, Blanca
dc.contributor.author
Guillen, Ana N
dc.contributor.author
Ribó Jacobi, Marc
dc.contributor.author
Requena, Manuel
dc.contributor.author
Chavarría-Miranda, Alba
dc.contributor.author
Siegler, James
dc.contributor.author
Arenillas, Juan F.
dc.date.accessioned
2025-10-24T08:49:55Z
dc.date.available
2025-10-24T08:49:55Z
dc.date.issued
2022-01-28T08:00:45Z
dc.date.issued
2022-01-28T08:00:45Z
dc.identifier
Siegler JE, Cardona P, Arenillas JF, Talavera B, Guillen AN, Chavarría-Miranda A, et al. Cerebrovascular events and outcomes in hospitalized patients with COVID-19: The SVIN COVID-19 Multinational Registry. Int J Stroke. 2021 Jun;16(4):437–47.
dc.identifier
https://hdl.handle.net/11351/6926
dc.identifier
10.1177/1747493020959216
dc.identifier
000575449700001
dc.identifier.uri
http://hdl.handle.net/11351/6926
dc.description.abstract
Totes les malalties cerebrovasculars/ictus; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Trombosi venosa cerebral
dc.description.abstract
Todas las enfermedades cerebrovasculares/ictus; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Trombosis venosa cerebral
dc.description.abstract
All cerebrovascular diseases/stroke; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Cerebral venous thrombosis
dc.description.abstract
Background
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients.
Aim
To summarize the findings of a multinational observational cohort of patients with SARS-CoV-2 and cerebrovascular disease.
Methods
Retrospective observational cohort of consecutive adults evaluated in the emergency department and/or admitted with coronavirus disease 2019 (COVID-19) across 31 hospitals in four countries (1 February 2020–16 June 2020). The primary outcome was the incidence rate of cerebrovascular events, inclusive of acute ischemic stroke, intracranial hemorrhages (ICH), and cortical vein and/or sinus thrombosis (CVST).
Results
Of the 14,483 patients with laboratory-confirmed SARS-CoV-2, 172 were diagnosed with an acute cerebrovascular event (1.13% of cohort; 1130/100,000 patients, 95%CI 970–1320/100,000), 68/171 (40.5%) were female and 96/172 (55.8%) were between the ages 60 and 79 years. Of these, 156 had acute ischemic stroke (1.08%; 1080/100,000 95%CI 920–1260/100,000), 28 ICH (0.19%; 190/100,000 95%CI 130–280/100,000), and 3 with CVST (0.02%; 20/100,000, 95%CI 4–60/100,000). The in-hospital mortality rate for SARS-CoV-2-associated stroke was 38.1% and for ICH 58.3%. After adjusting for clustering by site and age, baseline stroke severity, and all predictors of in-hospital mortality found in univariate regression (p < 0.1: male sex, tobacco use, arrival by emergency medical services, lower platelet and lymphocyte counts, and intracranial occlusion), cryptogenic stroke mechanism (aOR 5.01, 95%CI 1.63–15.44, p < 0.01), older age (aOR 1.78, 95%CI 1.07–2.94, p = 0.03), and lower lymphocyte count on admission (aOR 0.58, 95%CI 0.34–0.98, p = 0.04) were the only independent predictors of mortality among patients with stroke and COVID-19.
Conclusions
COVID-19 is associated with a small but significant risk of clinically relevant cerebrovascular events, particularly ischemic stroke. The mortality rate is high for COVID-19-associated cerebrovascular complications; therefore, aggressive monitoring and early intervention should be pursued to mitigate poor outcomes.
dc.description.abstract
The author(s) received no financial support for the research, authorship, and/or publication of this article.
dc.format
application/pdf
dc.format
application/pdf
dc.publisher
SAGE Publications
dc.relation
International Journal of Stroke;16(4)
dc.relation
https://doi.org/10.1177/1747493020959216
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
COVID-19 (Malaltia) - Complicacions
dc.subject
Malalties cerebrovasculars - Epidemiologia
dc.subject
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
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Other subheadings::Other subheadings::Other subheadings::/complications
dc.subject
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders
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Other subheadings::Other subheadings::Other subheadings::/epidemiology
dc.subject
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
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Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología
dc.title
Cerebrovascular events and outcomes in hospitalized patients with COVID-19: The SVIN COVID-19 Multinational Registry
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
