Sistema de Salut de Catalunya
Institut Català de la Salut
[Cruz-Lemini M] Department of Gynecology and Obstetrics, Women and Perinatal Health Research Group, Biomedical Research Institute (IIB-Sant Pau), Santa Creu i Sant Pau University Hospital, Barcelona, Spain. [Ferriols Perez E] Department of Gynecology and Obstetrics, Parc de Salut Mar University Hospital, Barcelona, Spain. [de la Cruz Conty ML] Fundacion de Investigacion Biomedica, Puerta de Hierro University Hospital of Majadahonda, Madrid, Spain. [Caño Aguilar A] Department of Gynecology and Obstetrics, San Cecilio University Hospital of Granada, Granada, Spain. [Encinas Pardilla MB] Department of Gynecology and Obstetrics, Puerta de Hierro University Hospital of Majadahonda, Madrid, Spain. [Prats Rodríguez P] Department of Gynecology and Obstetrics, Dexeus University Hospital, Barcelona, Spain. [Rodriguez Vicente A] Departament de Ginecologia i Obstetricia, Hospital Universitari de Girona Dr. Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain
Hospital Universitari de Girona Dr Josep Trueta
2022-01-27T13:07:24Z
2022-01-27T13:07:24Z
2021-01-15
Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Embaràs; Infecció asimptomàtica
Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Embarazo; Infección asintomática
Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Pregnancy; Asymptomatic infection
Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13-3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms.
This project was supported by public funds obtained in competitive calls: Grant COV20/00021 (EUR 43,000 from the Instituto de Salud Carlos III—Spanish Ministry of Health and co-financed with Fondo Europeo de Desarrollo Regional (FEDER) funds. Dr Cruz-Lemini is supported by a Juan Rodés contract JR19/00047, Instituto de Salud Carlos III—Spanish Ministry of Health. The funding bodies had no role in the study design, in the collection or analysis of the data, or in manuscript writing.
Article
English
COVID-19 (Malaltia); Embaràs; DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections; PHENOMENA AND PROCESSES::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproduction::Pregnancy; DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Asymptomatic Diseases::Asymptomatic Infections; ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus; FENÓMENOS Y PROCESOS::fenómenos fisiológicos reproductivos y urinarios::fenómenos fisiológicos de la reproducción::reproducción::embarazo; ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::enfermedades asintomáticas::infecciones asintomáticas
MDPI
Viruses;13(1)
https://doi.org/10.3390/v13010112
Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/
