dc.contributor
Institut Català de la Salut
dc.contributor
[Geraldes R, Juryńczyk M, Rodrigues dos Passos G] Nuffield Department of Clinical Neurosciences, Oxford, UK. [Pichler A] Department of Neurology, Medical University of Graz, Graz, Austria/Division of Neuroradiology, Vascular & Interventional Radiology, Medical University of Graz, Graz, Austria. [Chung K] NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London Institute of Neurology, London, UK. [Hagens M] MS Center Amsterdam, Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. [Auger C, Rovira A] Secció de Neuroradiologia, Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Sastre-Garriga J] Servei de Neurologia/ Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Geraldes, Ruth
dc.contributor.author
Juryńczyk, Maciej
dc.contributor.author
Passos, Giordani
dc.contributor.author
Pichler, Alexander
dc.contributor.author
Hagens, Marloes
dc.contributor.author
Auger Acosta, Cristina
dc.contributor.author
Rovira Cañellas, Alex
dc.contributor.author
Sastre Garriga, Jaume
dc.contributor.author
Chung, Karen
dc.date.accessioned
2025-10-24T10:19:56Z
dc.date.available
2025-10-24T10:19:56Z
dc.date.issued
2022-01-14T09:28:31Z
dc.date.issued
2022-01-14T09:28:31Z
dc.identifier
Geraldes R, Juryńczyk M, Rodrigues dos Passos G, Pichler A, Chung K, Hagens M, et al. The role of pontine lesion location in differentiating multiple sclerosis from vascular risk factor-related small vessel disease. Mult Scler J. 2021 May;27(6):968–72.
dc.identifier
https://hdl.handle.net/11351/6799
dc.identifier
10.1177/1352458520943777
dc.identifier
000556869200001
dc.identifier.uri
http://hdl.handle.net/11351/6799
dc.description.abstract
Esclerosi múltiple; Diagnòstic diferencial; Imatges
dc.description.abstract
Esclerosis múltiple; Diagnóstico diferencial; Imagen
dc.description.abstract
Multiple sclerosis; Differential diagnosis; Imaging
dc.description.abstract
Background:
Differentiating multiple sclerosis (MS) from vascular risk factor (VRF)-small vessel disease (SVD) can be challenging.
Objective and Methods:
In order to determine whether or not pontine lesion location is a useful discriminator of MS and VRF-SVD, we classified pontine lesions on brain magnetic resonance imaging (MRI) as central or peripheral in 93 MS cases without VRF, 108 MS patients with VRF and 43 non-MS cases with VRF.
Results:
MS without VRF were more likely to have peripheral pons lesions (31.2%, 29/93) than non-MS with VRF (0%, 0/43) (Exp(B) = 29.8; 95% confidence interval (CI) = (1.98, 448.3); p = 0.014) but there were no significant differences regarding central pons lesions between MS without VRF (5.4%, 5/93) and non-MS with VRF patients (16.3%, 7/43) (Exp(B) = 0.89; 95% CI = (0.2, 3.94); p = 0.87). The presence of peripheral pons lesions discriminated between MS and VRF-SVD with 100% (95% CI = (91.8, 100)) specificity. The proportion of peripheral pons lesions in MS with VRF (30.5%, 33/108) was similar to that seen in MS without VRF (31.2%, 29/93, p = 0.99). Central lesions occurred in similar frequency in MS with VRF (8.3%, 9/108) and non-MS with VRF (16.3%, 7/43, p = 0.15).
Conclusion:
Peripheral pons lesion location is a good discriminator of MS from vascular lesions.
dc.description.abstract
The author(s) received no financial support for the research, authorship and/or publication of this article.
dc.format
application/pdf
dc.format
application/pdf
dc.publisher
SAGE Publications
dc.relation
Multiple Sclerosis Journal;27(6)
dc.relation
https://doi.org/10.1177/1352458520943777
dc.rights
Attribution-NonCommercial 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Esclerosi múltiple
dc.subject
Cervell - Vasos sanguinis - Malalties
dc.subject
Imatgeria per ressonància magnètica
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging
dc.subject
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
dc.subject
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Cerebral Small Vessel Diseases
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades de los pequeños vasos cerebrales
dc.title
The role of pontine lesion location in differentiating multiple sclerosis from vascular risk factor-related small vessel disease
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
