dc.contributor
[Mayneris-Perxachs J] Departament de Diabetis, Endocrinologia i Nutrició, Hospital Universitari Dr. Josep Trueta, Girona, Spain. Grup d'Eumetabolisme i Salut, Institut d’Investigació Biomèdica de Girona (IDIBGI), Salt, Spain. Centre d'Investigació Biomèdica en Xarxa de Fisiopatologia de l'Obesitat i la Nutrició (CIBEROBN), Madrid, Spain. Institut d'Investigació Biomèdica de Girona (IDIBGI), Salt, Spain. [Moreno-Navarrete JM] Departament de Diabetis, Endocrinologia i Nutrició, Hospital Universitari Dr. Josep Trueta, Girona, Spain. Grup d'Eumetabolisme i Salut, Institut d’Investigació Biomèdica de Girona (IDIBGI), Salt, Spain. Centre d'Investigació Biomèdica en Xarxa de Fisiopatologia de l'Obesitat i la Nutrició (CIBEROBN), Madrid, Spain. Departament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, Girona, Spain. Institut d'Investigació Biomèdica de Girona (IDIBGI), Salt, Spain. [Ballanti M] Departament de Medicina de Sistemes, Universitat de Roma Tor Vergata, Roma, Italy. Centre d'Aterosclerosi, Policlinico Tor Vergata, Roma, Italy. [Monteleone G, Paoluzi OA] Departament de Medicina de Sistemes, Universitat de Roma Tor Vergata, Roma, Italy. [Mingrone G] Departament de Medicina Interna, Universitat Catòlica, Roma, Italy. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Itàlia. Diabetes and Nutritional Sciences, Hodgkin Building, Guy's Campus, King's College London, London, United Kingdom. [Garre J] Departament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, Girona, Spain. Institut d’Investigació Biomèdica de Girona (IDIBGI), Salt, Spain. Grup de Recerca en Envelliment, Discapacitat i Salut, Institut d’Investigació Biomèdica de Girona (IDIBGI), Salt, Spain. Departament d’Infermeria, Universitat de Girona, Girona, Spain. [Puig J] Departament de Radiologia (IDI), Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain. [Fernández-Real JM] Departament de Diabetis, Endocrinologia i Nutrició, Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain
dc.contributor
Institut d'Assistència Sanitària
dc.contributor.author
Moreno-Navarrete, José Maria
dc.contributor.author
Ballanti, Marta
dc.contributor.author
Monteleone, Giovanni
dc.contributor.author
Paoluzi, Omero Alessandro
dc.contributor.author
Mingrone, Geltrude
dc.contributor.author
Garre-Olmo, Josep
dc.contributor.author
Mayneris-Perxachs, Jordi
dc.contributor.author
Puig, Josep
dc.contributor.author
Fernández-Real, Jose Manuel
dc.date.accessioned
2025-10-24T07:50:24Z
dc.date.available
2025-10-24T07:50:24Z
dc.date.issued
2021-11-23T07:57:24Z
dc.date.issued
2021-11-23T07:57:24Z
dc.date.issued
2021-11-08
dc.identifier
Mayneris-Perxachs J, Moreno-Navarrete JM, Ballanti M, Monteleone G, Paoluzi OA, Mingrone G, et al. Lipidomics and metabolomics signatures of SARS-CoV-2 mediators/receptors in peripheral leukocytes, jejunum and colon. Comput Struct Biotechnol J. 2021 Nov 8;19:6080-9.
dc.identifier
https://hdl.handle.net/11351/6582
dc.identifier
10.1016/j.csbj.2021.11.007
dc.identifier.uri
https://hdl.handle.net/11351/6582
dc.description.abstract
Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Lipidómicas; Metabolómicas; Receptores virales
dc.description.abstract
Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Lipidòmiques; Metabolòmiques; Receptors virals
dc.description.abstract
Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Lipidomics; Metabolomics; Viral receptors
dc.description.abstract
Cell surface receptor-mediated viral entry plays a critical role in this infection. Well-established SARS-CoV-2 receptors such as ACE2 and TMPRSS2 are highly expressed in the gastrointestinal tract. In fact, there are evidences that SARS-CoV-2 infects epithelial cells from the digestive system. However, emerging research has identified novel mediators such as DPP9, TYK2, and CCR2, all playing a critical role in inflammation. We evaluated the expression of SARS-CoV-2 receptors in peripheral leukocytes (n=469), jejunum (n=30), and colon (n=37) of three independent cohorts by real-time PCR, RNA-sequencing, and microarray transcriptomics. We also performed HPCL-MS/MS lipidomics and metabolomics analyses to identify signatures linked to SARS-CoV-2 receptors. We found markedly higher peripheral leukocytes ACE2 expression levels in women compared to men, whereas the intestinal expression of TMPRSS2 was positively associated with BMI. Consistent lipidomics signatures associated with the expression of these mediators were found in both tissues and peripheral leukocytes involving n-3 long-chain PUFAs and arachidonic acid-derived eicosanoids, which play a key role in the regulation of inflammation and may interfere with viral entry and replication. Medium- and long-chain hydroxy acids, which have shown to interfere in viral replication, were also liked to SARS-CoV2 receptors. Gonadal steroids were also associated with the expression of some of these receptors, even after controlling for sex. The expression of SARS-CoV2 receptors was associated with several metabolic and nutritional traits in different cell types. This information may be useful in the design of potential therapies targeted at coronavirus entry.
dc.format
application/pdf
dc.relation
Computational and Structural Biotechnology Journal;19
dc.relation
https://dx.doi.org/10.1016%2Fj.csbj.2021.11.007
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
COVID-19 (Malaltia)
dc.subject
Receptors cel·lulars
dc.subject
Àcids grassos omega 3
dc.subject
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
dc.subject
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Virus
dc.subject
CHEMICALS AND DRUGS::Lipids::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Lipids::Fatty Acids, Omega-3
dc.subject
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de membranas::receptores de superficie celular::receptores de virus
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::lípidos::lípidos::ácidos grasos::ácidos grasos insaturados::lípidos::ácidos grasos omega 3
dc.title
Lipidomics and metabolomics signatures of SARS-CoV-2 mediators/receptors in peripheral leukocytes, jejunum and colon
dc.type
info:eu-repo/semantics/article
