dc.contributor
Institut Català de la Salut
dc.contributor
[Ramos-Araque ME] Institute of Biomedical Research of Salamanca, Department of Neurology, Hospital Universitario de Salamanca, Salamanca, Spain. Department of Neurology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain. [Siegler JE] Cooper Neurologic Institute, Cooper University Hospital, Camden, NJ, USA. [Ribo M, Requena M] Unitat d’Ictus, Servei de Neurologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [López C, de Lera M] Department of Neurology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Ramos-Araque, María E.
dc.contributor.author
Ribó Jacobi, Marc
dc.contributor.author
López, Cristina
dc.contributor.author
de Lera, Mercedes
dc.contributor.author
Requena, Manuel
dc.contributor.author
Siegler, James
dc.date.accessioned
2025-10-24T08:54:21Z
dc.date.available
2025-10-24T08:54:21Z
dc.date.issued
2021-06-11T06:36:54Z
dc.date.issued
2021-06-11T06:36:54Z
dc.date.issued
2021-01-30
dc.identifier
Ramos-Araque ME, Siegler JE, Ribo M, Requena M, López C, de Lera M, et al. Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry. BMC Neurol. 2021 Jan 30;21:43.
dc.identifier
https://hdl.handle.net/11351/6051
dc.identifier
10.1186/s12883-021-02075-1
dc.identifier
000616461000001
dc.identifier.uri
http://hdl.handle.net/11351/6051
dc.description.abstract
Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Ictus; Mortalitat
dc.description.abstract
Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Ictus; Mortalidad
dc.description.abstract
Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Stroke; Mortality
dc.description.abstract
Background and purpose Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause of which is frequently cryptogenic. In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes and in-hospital mortality among patients according to stroke etiology. Methods We explored clinical characteristics and short-term outcomes of consecutively evaluated patients 18 years of age or older with acute ischemic stroke (AIS) and laboratory-confirmed COVID-19 from 31 hospitals in 4 countries (3/1/20–6/16/20). Results Of the 14.483 laboratory-confirmed patients with COVID-19, 156 (1.1%) were diagnosed with AIS. Sixty-one (39.4%) were female, 84 (67.2%) white, and 88 (61.5%) were between 60 and 79 years of age. The most frequently reported etiology of AIS was cryptogenic (55/129, 42.6%), which was associated with significantly higher white blood cell count, c-reactive protein, and D-dimer levels than non-cryptogenic AIS patients (p</=0.05 for all comparisons). In a multivariable backward stepwise regression model estimating the odds of in-hospital mortality, cryptogenic stroke mechanism was associated with a fivefold greater odds in-hospital mortality than strokes due to any other mechanism (adjusted OR 5.16, 95%CI 1.41–18.87, p = 0.01). In that model, older age (aOR 2.05 per decade, 95%CI 1.35–3.11, p < 0.01) and higher baseline NIHSS (aOR 1.12, 95%CI 1.02–1.21, p = 0.01) were also independently predictive of mortality. Conclusions Our findings suggest that cryptogenic stroke among COVID-19 patients carries a significant risk of early mortality.
dc.description.abstract
MER-A was funded by The Instituto de Salud Carlos III (JR19/00020), Spain.
dc.format
application/pdf
dc.relation
BMC Neurology;21
dc.relation
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-021-02075-1
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info:eu-repo/grantAgreement/ES/PE2017-2020/JR19%2F00020
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Isquèmia cerebral - Mortalitat
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Malalties - Factors de risc
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COVID-19 (Malaltia)
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DISEASES::Cardiovascular Diseases::Vascular Diseases::Cerebrovascular Disorders::Brain Ischemia
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Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
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ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
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DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
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ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::trastornos cerebrovasculares::isquemia cerebral
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Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
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TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo
dc.subject
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
dc.title
Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
