dc.contributor
[Giner-Soriano M] Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Bellaterra, Spain. [Marsal J] Unitat d’Epidemiologia, Servei de Cardiologia, Hospital Universitari Vall d’Hebron, Barcelona, Spain. [Gomez-Lumbreras A] Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Bellaterra, Spain. Facultat de Medicina, Universitat de Girona, Girona, Spain. [Morros R] Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Bellaterra, Spain. Institut Català de la Salut, Barcelona, Spain
dc.contributor
IDIAP Jordi Gol
dc.contributor.author
Marsal Mora, Josep Ramon
dc.contributor.author
Morros, Rosa
dc.contributor.author
Giner-Soriano, Maria
dc.contributor.author
Gomez-Lumbreras, Ainhoa
dc.date.accessioned
2025-10-24T10:42:28Z
dc.date.available
2025-10-24T10:42:28Z
dc.date.issued
2021-05-26T12:55:23Z
dc.date.issued
2021-05-26T12:55:23Z
dc.date.issued
2021-05-24
dc.identifier
Giner-Soriano M, Marsal JR, Gomez-Lumbreras A, Morros R. Risk of ischaemic stroke associated with antiepileptic drugs: a population-based case-control study in Catalonia. BMC Neurol. 2021 May 24;21:208.
dc.identifier
https://hdl.handle.net/11351/5976
dc.identifier
10.1186/s12883-021-02237-1
dc.identifier.uri
https://hdl.handle.net/11351/5976
dc.description.abstract
Antiepileptic drugs; Stroke; Electronic health records
dc.description.abstract
Medicaments antiepilèptics; Embòlia; Registres electrònics de salut
dc.description.abstract
Medicamentos antiepilépticos; Embolia; Registros electrónicos de salud
dc.description.abstract
Background
Cerebrovascular disorders have occurred more frequently in some Central Nervous System (CNS) disorders, such as epilepsy. Some CNS drugs have been associated with increased stroke risk. Our aim was to estimate the risk of ischaemic stroke in patients exposed to antiepileptic drugs (AED).
Methods
Population-based matched case-control study using SIDIAP database, based in electronic health records from primary healthcare from Catalonia, Spain. Cases were those patients with a registered diagnosis of first stroke during 2009–2014. Up to 10 controls were selected for each case and matched by sex, age, and geographic area and without a prior diagnosis of stroke. We considered global drug exposure to AED, past and current exposure and exposure in monotherapy to each AED.
Results
2,865 cases and 19,406 controls were exposed to AED during the study period. Global exposure to levetiracetam [(ORadj3.3, CI95 % 2.8-4.0)], phenytoin [ORadj1.5, CI95 % 1.2–41.9)], and valproic acid [(ORadj 1.3, CI95 % 1.1–1.6)], showed significantly association to ischaemic stroke that was also maintained with current exposure of levetiracetam [ORadj4.1, CI95 % 3.3–5.2)] and valproic acid [ORadj1.4, CI95 % 1.1–1.9)]. Current levetiracetam monotherapy showed a very high risk of ischaemic stroke [(ORadj 5.1, CI95 % 3.7–6.9)].
Conclusions
Drugs used for other conditions than epilepsy (pregabalin, gabapentin) were the most used AED and both did not show a risk. Levetiracetam shows a risk for stroke even when assessed in current monotherapy. The lack of data regarding the link with diagnosis and severity in our study makes it necessary to conduct further studies to confirm or dismiss our results, focussing on levetiracetam.
dc.description.abstract
This study has been funded by Bioibérica S.A.
dc.format
application/pdf
dc.relation
BMC Neurology;21
dc.relation
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-021-02237-1
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Anticonvulsius - Efectes secundaris - Catalunya
dc.subject
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Anticonvulsants
dc.subject
Other subheadings::Other subheadings::Other subheadings::/adverse effects
dc.subject
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Stroke
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::fármacos del sistema nervioso central::anticonvulsivantes
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascular
dc.title
Risk of ischaemic stroke associated with antiepileptic drugs: a population-based case-control study in Catalonia
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
