dc.contributor
Institut Català de la Salut
dc.contributor
[Loppi S] A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. Department of Immunobiology, University of Arizona, Tucson, Arizona, USA. [Korhonen P, Turunen TA, Turunen MP] A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. [Bouvy-Liivrand M] School of Medicine, University of Eastern Finland, Kuopio, Finland. [Caligola S] Department of Computer Science, University of Verona, Verona, Italy. [Rosell A, García-Berrocoso T, Montaner J] Laboratori de Malalties Neurovasculars, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Loppi, Sanna
dc.contributor.author
Korhonen, Paula
dc.contributor.author
Bouvy-Liivrand, Maria
dc.contributor.author
Caligola, Simone
dc.contributor.author
Turunen, Tiia A
dc.contributor.author
Turunen, Mikko P
dc.contributor.author
Garcia Berrocoso, Teresa
dc.contributor.author
Montaner Villalonga, Joan
dc.contributor.author
Rosell Novel, Anna
dc.date.accessioned
2025-10-24T08:57:22Z
dc.date.available
2025-10-24T08:57:22Z
dc.date.issued
2021-05-14T12:13:22Z
dc.date.issued
2021-05-14T12:13:22Z
dc.identifier
Loppi S, Korhonen P, Bouvy‐Liivrand M, Caligola S, Turunen TA, Turunen MP, et al. Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR‐127 in aged animals. Aging Cell. 2021 Jan;20(1).
dc.identifier
https://hdl.handle.net/11351/5949
dc.identifier
10.1111/acel.13287
dc.identifier
000602656900001
dc.identifier.uri
http://hdl.handle.net/11351/5949
dc.description.abstract
Envelliment; Inflamació; MicroARN
dc.description.abstract
Envejecimiento; Inflamación; MicroARN
dc.description.abstract
Aging; Inflammation; MicroRNA
dc.description.abstract
Ischemic stroke, the third leading cause of death in the Western world, affects mainly the elderly and is strongly associated with comorbid conditions such as atherosclerosis or diabetes, which are pathologically characterized by increased inflammation and are known to influence the outcome of stroke. Stroke incidence peaks during influenza seasons, and patients suffering from infections such as pneumonia prior to stroke exhibit a worse stroke outcome. Earlier studies have shown that comorbidities aggravate the outcome of stroke, yet the mediators of this phenomenon remain obscure. Here, we show that acute peripheral inflammation aggravates stroke‐induced neuronal damage and motor deficits specifically in aged mice. This is associated with increased levels of plasma proinflammatory cytokines, rather than with an increase of inflammatory mediators in the affected brain parenchyma. Nascent transcriptomics data with mature microRNA sequencing were used to identify the neuron‐specific miRNome, in order to decipher dysregulated miRNAs in the brains of aged animals with stroke and co‐existing inflammation. We pinpoint a previously uninvestigated miRNA in the brain, miR‐127, that is highly neuronal, to be associated with increased cell death in the aged, LPS‐injected ischemic mice. Target prediction tools indicate that miR‐127 interacts with several basally expressed neuronal genes, and of these we verify miR‐127 binding to Psmd3. Finally, we report reduced expression of miR‐127 in human stroke brains. Our results underline the impact of peripheral inflammation on the outcome of stroke in aged subjects and pinpoint molecular targets for restoring endogenous neuronal capacity to combat ischemic stroke.
dc.description.abstract
This study was supported by Emil Aaltonen Foundation, Academy of Finland and Finnish Cultural Foundation.
dc.format
application/pdf
dc.relation
Aging Cell;20(1)
dc.relation
https://doi.org/10.1111/acel.13287
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Isquèmia cerebral
dc.subject
DISEASES::Cardiovascular Diseases::Vascular Diseases::Cerebrovascular Disorders::Stroke
dc.subject
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Brain Ischemia
dc.subject
ORGANISMS::Eukaryota::Animals
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascular
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::isquemia cerebral
dc.subject
ORGANISMOS::Eukaryota::animales
dc.title
Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR‐127 in aged animals
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
